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製品番号: HY-144731

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gp120-IN-2

gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 7.5 µM and CC₅₀ of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells.

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CAS 番号: 123629-42-5
分子式: C₁₅H₁₈N₂O₅
分子量:306.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

gp120-IN-2 構造式

CAS 番号: 123629-42-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

HIV-1

7.5 μM (IC₅₀)

HIV-1

112.93 μM (CC₅₀)

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	17.5 μg/mL Compound: BA20	Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
HT-29	GI₅₀	28.1 μg/mL Compound: BA20	Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
NCI/ADR-RES	GI₅₀	0.25 μg/mL Compound: BA20	Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
NCI-H460	GI₅₀	125.6 μg/mL Compound: BA20	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
OVCAR-3	GI₅₀	1.7 μg/mL Compound: BA20	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
PC-3	GI₅₀	46.3 μg/mL Compound: BA20	Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]
SUP-T1	CC₅₀	140.97 μM Compound: 4l	Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay	[PMID: 34839157]
U-251	GI₅₀	4.5 μg/mL Compound: BA20	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 22410248]

化学情報

CAS 番号 123629-42-5
分子量 306.31
分子式 C₁₅H₁₈N₂O₅
SMILES

CCOC(C1=C(NC(NC1C2=CC(OC)=C(C=C2)O)=O)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Senapathi J, et al. Design, Synthesis, and Antiviral activity of 1,2,3,4-Tetrahydropyrimidine derivatives acting as novel entry inhibitors to target at "Phe43 cavity" of HIV-1 gp120. Bioorg Med Chem. 2021 Dec 15;52:116526. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
数量:
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gp120-IN-2

HIV アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

gp120-IN-2 関連分類

HY-144731 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target