Antimalarial agent 12
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli.
For research use only. We do not sell to patients.
- CAS No.: 2715225-58-2
- Formula: C26H18BrClN2O2
- Molecular Weight:505.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>50000 nM
Compound: (R)-3b
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based fluorescence assay
|
[PMID: 35300082] |
| Hepatocyte | CC50 |
>10000 nM
Compound: (R)-3b
|
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
Cytotoxicity against human primary hepatocytes assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based fluorescence assay
|
[PMID: 35300082] |
Chemical Information
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CAS No. 2715225-58-2
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Molecular Weight 505.79
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Formula C26H18BrClN2O2
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SMILES
O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)