Antiviral agent 52
Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM.
For research use only. We do not sell to patients.
- CAS No.: 101784-44-5
- Formula: C18H20Cl2N2
- Molecular Weight:335.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | CC50 |
>31.6 μM
Compound: 30
|
Cytotoxicity against human primary hepatocytes assessed as ATP level by luminescence analysis
Cytotoxicity against human primary hepatocytes assessed as ATP level by luminescence analysis
|
[PMID: 26599718] |
| HepG2 | CC50 |
31.6 μM
Compound: 30
|
Cytotoxicity against human HepG2 cells assessed as ATP level by luminescence analysis
Cytotoxicity against human HepG2 cells assessed as ATP level by luminescence analysis
|
[PMID: 26599718] |
| Huh-7 | CC50 |
21.3 μM
Compound: 30
|
Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis
Cytotoxicity against human Huh7.5.1 cells assessed as ATP level by luminescence analysis
|
[PMID: 26599718] |
Pharmacokinetic Analysis of Antiviral agent 52 in CD-1 mouse[1]
| - | plasma | liver | liver/plasma |
| AUClast (μM·h) | 27.5 | 429 | 16 |
| AUCINF (μM·h) | 29.8 | 495 | 17 |
| T1/2 (h) | 6.7 | 8.5 | - |
| Tmax (h) | 0.083 | 0.083 | - |
| Cmax (h) | 5.28 | 57.0 | 11 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 101784-44-5
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Molecular Weight 335.27
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Formula C18H20Cl2N2
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SMILES
CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)