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Cat. No.: HY-147723

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HIV-1 inhibitor-39

HIV-1 inhibitor-39 (compound 3c) is a potent HIV-1 inhibitor with an EC₅₀ of >112.88 µM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC₅₀ of 15.75 µM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC₅₀ of 112.9 µM.

For research use only. We do not sell to patients.

CAS No.: 2414099-82-2
Formula: C₂₀H₁₇ClN₄O₄S₄
Molecular Weight:541.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HIV-1 inhibitor-39 Chemical Structure

CAS No.: 2414099-82-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1

>112.88 μM (EC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	112.9 μM Compound: 3c	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 5 days by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 5 days by MTT assay	[PMID: 32197813]
MT4	EC₅₀	>112.88 μM Compound: 3c	Antiviral activity against HIV1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against HIV1 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 32197813]

Chemical Information

CAS No. 2414099-82-2
Molecular Weight 541.09
Formula C₂₀H₁₇ClN₄O₄S₄
SMILES

O=C(NC1=CC=C(S(=O)(C)=O)C=C1)CSC2=NN=C(N3C(C4=CC=CC(Cl)=C4)SCC3=O)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Buemi MR, et al. Inhibition of HIV-1 RT activity by a new series of 3-(1,3,4-thiadiazol-2-yl)thiazolidin-4-one derivatives. Bioorg Med Chem. 2020 Apr 15;28(8):115431. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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HIV-1 inhibitor-39

All HIV Isoforms