Tazettine

Cat. No.: HY-N6622: Data Sheet Handling Instructions
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Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL).

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Tazettine Chemical Structure

CAS No. : 507-79-9

Size	Stock	Quantity
1 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	11.1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
A549	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
A549	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23190013]
B16-F10	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
Col2	ED₅₀	5 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
HL-60	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23190013]
HT	ED₅₀	11.8 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
HT-29	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 23190013]
HepG2	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23190013]
Hs 683	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
K562	IC₅₀	> 10 μM Compound: 4	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23190013]
KB	ED₅₀	7.3 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
KB-V1	ED₅₀	> 20 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
LNCaP	ED₅₀	5.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
Lu1	ED₅₀	11.1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
P388	ED₅₀	1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
SK-MEL	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
SK-MEL-2	ED₅₀	12.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
U-373MG ATCC	IC₅₀	> 10 μM Compound: 10	Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
ZR-75-1	ED₅₀	6.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]

Molecular Weight

331.36

Formula

C₁₈H₂₁NO₅

CAS No.

507-79-9

SMILES

O[C@@]12[C@]3([C@@](C[C@@H](C=C3)OC)([H])N(C2)C)C4=CC(OCO5)=C5C=C4CO1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brine ND, et al. A dinitrogenous alkaloid from Cyrtanthus obliquus. Phytochemistry. 2002 Oct;61(4):443-7. [Content Brief]

Tazettine Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tazettine507-79-9OthersCyrtanthus obliquusAmaryllidaceaeAlkaloidsDinitrogenous alkaloids11a-Hydroxygalanthamine3-EpimacronineNarcissidineObliquineTrisphaeridineInhibitorinhibitorinhibit

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Tazettine

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Tazettine Related Classifications

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