Cytotoxicity of Hymenocallis expansa alkaloids

  • J Nat Prod. 1993 Aug;56(8):1423-5. doi: 10.1021/np50098a030.
M D Antoun  1 ,  N T Mendoza ,  Y R Ríos ,  G R Proctor ,  D B Wickramaratne ,  J M Pezzuto ,  A D Kinghorn
Affiliations
  • 1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
PMID: 8229020 DOI: 10.1021/np50098a030
Abstract

From the bulbs and leaves of Hymenocallis expansa (Amaryllidaceae), three alkaloid constituents were identified: (+)-tazettine, (+)-hippeastrine, and (-)-haemanthidine. These Alkaloids demonstrated significant cytotoxicity when tested against a panel of human and murine tumor cell lines.