A dinitrogenous alkaloid from Cyrtanthus obliquus

  • Phytochemistry. 2002 Oct;61(4):443-7. doi: 10.1016/s0031-9422(02)00206-6.
Natalie D Brine  1 ,  William E Campbell ,  Jaume Bastida ,  Maria R Herrera ,  Francesc Viladomat ,  Carles Codina ,  Peter J Smith
Affiliations
  • 1. Pharmacology Division, Department of Medicine, University of Cape Town, Observatory 7925, South Africa.
PMID: 12377241 DOI: 10.1016/s0031-9422(02)00206-6
Abstract

The ethanolic extract of bulbs of Cyrtanthus obliquus (L.f.) Ait yielded the new dinitrogenous alkaloid obliquine (1), 3S, 4aS, 11S, 10bS-3,4,4a,13,11,5,6-heptahydro-5[2-(4-hydroxyphenyl)ethyl]-3-methoxy-13-methyl-[1,3-dioxolo[4,5-g]indolo[3,3a-c]-isoquinolin-12-one, together with the five known structures 11alpha-hydroxygalanthamine, 3-epimacronine, narcissidine, tazettine and trisphaeridine. All structures were established using 1D and 2D NMR techniques and HREIMS. The Alkaloids were tested for cytotoxicity against two mammalian cell lines and did not show activity at concentrations up to 100 microg/ml.

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