HCV-IN-34
HCV-IN-34 (compound 3i) is an orally active and potent HCV entry inhibitor. HCV-IN-35 shows excellent antiviral activity, with an EC50 of 0.010 μM and a CC50 (half-maximal cytotoxic concentration) of 8.23 μM.
For research use only. We do not sell to patients.
- CAS No.: 2425805-22-5
- Formula: C31H36ClN5
- Molecular Weight:514.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
EC50: 0.010 ± 0.003 μM (HCV)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7.5 | CC50 |
3.72 μM
Compound: 3i
|
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells infected with HCVcc assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
| Huh-7.5 | CC50 |
5.22 μM
Compound: 3i
|
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells carrying HCV subgenomic replicons assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
| Huh-7.5 | CC50 |
7.34 μM
Compound: 3i
|
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35050619] |
Chemical Information
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CAS No. 2425805-22-5
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Molecular Weight 514.10
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Formula C31H36ClN5
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SMILES
N#CC1=CC=C(N2CCN(C)CCC2)C=C1CN3CCN(C(C4=CC=C(Cl)C=C4)C5=CC=CC=C5)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)