1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. CHIKV-IN-3

CHIKV-IN-3 

Cat. No.: HY-144334
Handling Instructions

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC50 > 100 µM). Prophylactic effect.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CHIKV-IN-3 Chemical Structure

CHIKV-IN-3 Chemical Structure

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Description

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC50 > 100 µM). Prophylactic effect[1].

IC50 & Target

EC50: 1.55 µM (CHIKV-122508); 0.14 µM (CHIKV-6708)[1]

In Vitro

CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 µM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC50 of 1.55 µM and demonstrates low cytotoxicity (CC50=129.6 µM)[1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 µM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508
Concentration: 0.1-100 µM
Incubation Time: 24 hours
Result: Inhibited the CHIKV replication with an EC50 of 1.55 µM and demonstrated low cytotoxicity(CC50=129.6 µM)
Molecular Weight

383.95

Formula

C24H30ClNO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
CHIKV-IN-3
Cat. No.:
HY-144334
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