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  4. HIV-1 inhibitor-21

HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM).

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HIV-1 inhibitor-21

HIV-1 inhibitor-21 화학구조

CAS No. : 2554620-04-9

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HIV-1 inhibitor-21 Related Antibodies

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제품 설명

HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

IC50 & Target[1]

HIV-1 (WT)

12.7 nM (EC50)

HIV-1 (K103N)

10.4 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
MT4 CC50
10.2 μM
Compound: 9b
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
[PMID: 31735575]
분자량

476.53

화학식

C28H24N6O2
CAS No.
SMILES

N#CC1=CC=C(NC2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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HIV-1 inhibitor-21 Related Classifications

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Keywords:

HIV-1 inhibitor-212554620-04-9HIVHuman immunodeficiency virusAntiretroviralAnti-HIVAIDSHIV-1 K103NMT-4 cellsLow cytotoxicityInhibitorinhibitorinhibit

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상품명:
HIV-1 inhibitor-21
Cat. No.:
HY-146015
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