HIV-1 inhibitor-21
HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM).
For research use only. We do not sell to patients.
- CAS No.: 2554620-04-9
- Formula: C28H24N6O2
- Molecular Weight:476.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 12.7 nM (EC50) |
HIV-1 (K103N) 10.4 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
10.2 μM
Compound: 9b
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 31735575] |
Chemical Information
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CAS No. 2554620-04-9
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Molecular Weight 476.53
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Formula C28H24N6O2
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SMILES
N#CC1=CC=C(NC2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-21 Related Classifications
HY-146015 Related Classifications
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