Influenza virus-IN-4
Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2133818-85-4
- 分子式: C23H31FN2O4
- 分子量:418.50
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | CC50 |
>200 μM
Compound: 11e
|
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
|
[PMID: 32092589] |
Influenza virus-IN-4 (compound 11e) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 2133818-85-4
-
分子量 418.50
-
分子式 C23H31FN2O4
-
SMILES
O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NC/C=C/C2=CC=C(F)C=C2)C1)O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)