1. Anti-infection
  2. Influenza Virus
  3. Influenza virus-IN-4

Influenza virus-IN-4 

Cat. No.: HY-146001
Handling Instructions

Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice.

For research use only. We do not sell to patients.

Influenza virus-IN-4 Chemical Structure

Influenza virus-IN-4 Chemical Structure

CAS No. : 2133818-85-4

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Description

Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].

IC50 & Target

IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8)[1]

In Vitro

Influenza virus-IN-4 (compound 11e) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

418.50

Formula

C23H31FN2O4

CAS No.
SMILES

O=C(C1=C[[email protected]@H](OC(CC)CC)[[email protected]](NC(C)=O)[[email protected]@H](NC/C=C/C2=CC=C(F)C=C2)C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Influenza virus-IN-4
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HY-146001
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