2133818-85-4
Chemical Structure
Influenza virus-IN-4
- CAS No.: 2133818-85-4
- Formula:C23H31FN2O4
- Molecular Weight:418.50
IUPAC Name: (3R,4R,5S)-4-acetamido-5-(((E)-3-(4-fluorophenyl)allyl)amino)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
InChIKey: PPTCIZMCVZJIRY-YEKHMCODSA-N
SMILES: O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NC/C=C/C2=CC=C(F)C=C2)C1)O
Biological Activity: Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].
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Influenza virus-IN-4 | Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice. | |||||||||||||||||||||
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Keywords
