2. Anti-infection Cell Cycle/DNA Damage
  3. Dengue virus Flavivirus Virus Protease DNA/RNA Synthesis
  4. SP-471P

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

For research use only. We do not sell to patients.

SP-471P Chemical Structure

SP-471P Chemical Structure

CAS No. : 2768011-36-3

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SP-471P Related Antibodies

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Description

SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis[1].

IC50 & Target

EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
In Vitro

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471P Related Antibodies

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 6-54 hours
Result: Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line: Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
Concentration: 10 μM
Incubation Time: 30 hours
Result: Targeted the NS3int cleavage site of DENV.
Molecular Weight

604.50

Formula

C33H26BrN5O2
CAS No.
SMILES

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SP-471P Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-471P2768011-36-3Dengue virusFlavivirusVirus ProteaseDNA/RNA SynthesisDENVRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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