SP-471P
Based on 1 Customer Validation
SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 2768011-36-3
- Formula: C33H26BrN5O2
- Molecular Weight:604.50
-
Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Antiviral Compound Library
HY-L027
-
Anti-Aging Compound Library
HY-L034
-
Protease Inhibitor Library
HY-L147
-
Multi-Target Compound Library
HY-L176
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
All DNA/RNA Synthesis Isoforms
More
Biological Activity
EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μM
Compound: 32a; SP-471P
|
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
|
[PMID: 34298282] |
| PBMC | CC50 |
>100 μM
Compound: 32a; SP-471P
|
Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
|
[PMID: 34298282] |
SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human peripheral blood mononuclear cells (infected with ADE)[1]
-
Concentration:10 μM
-
Incubation Time:48 hours
-
Result:Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.
-
Cell Line:Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
-
Concentration:10 μM
-
Incubation Time:6-54 hours
-
Result:Reduced viral RNA synthesis.
-
Cell Line:Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
-
Concentration:10 μM
-
Incubation Time:30 hours
-
Result:Targeted the NS3int cleavage site of DENV.
Chemical Information
-
CAS No. 2768011-36-3
-
Appearance Solid
-
Molecular Weight 604.50
-
Formula C33H26BrN5O2
-
Color White to off-white
-
SMILES
N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SP-471P Related Classifications
HY-144645 Related Classifications
Powered by Bioz