SARS-CoV-2 3CLpro-IN-18
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.478 μM). SARS-CoV-2 3CLpro-IN-18 inhibits SARS-CoV-2 in Vero E6 cells (EC50= 2.499 μM) with low cytotoxicity (CC50 > 200 μM).
For research use only. We do not sell to patients.
- CAS No.: 3032604-29-5
- Formula: C17H13ClN2OS
- Molecular Weight:328.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
0.478 μM (SARS-CoV-2 3CLpro)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
264.5 μM
Compound: 3c
|
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
|
[PMID: 37594952] |
| Vero C1008 | EC50 |
2.499 μM
Compound: 3c
|
Antiviral activity against SARS-CoV-2 B1.617.2 (Delta) infected in african green monkey Vero E6 cells assessed as reduction in viral replication incubated for 24 hrs by qRT-PCR analysis
Antiviral activity against SARS-CoV-2 B1.617.2 (Delta) infected in african green monkey Vero E6 cells assessed as reduction in viral replication incubated for 24 hrs by qRT-PCR analysis
|
[PMID: 37594952] |
Chemical Information
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CAS No. 3032604-29-5
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Molecular Weight 328.82
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Formula C17H13ClN2OS
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SMILES
O=C(N1C2=CC(Cl)=CC=C2CCC3=CC=CC=C31)CSC#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)