1. Anti-infection
  2. HIV
  3. HIV-1 inhibitor-23

HIV-1 inhibitor-23 

Cat. No.: HY-146018
Handling Instructions

HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability.

For research use only. We do not sell to patients.

HIV-1 inhibitor-23 Chemical Structure

HIV-1 inhibitor-23 Chemical Structure

CAS No. : 2554622-28-3

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Description

HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability[1].

IC50 & Target[1]

HIV-1 (WT)

24.9 nM (EC50)

HIV-1 (K103N)

10.4 nM (EC50)

Molecular Weight

566.63

Formula

C30H26N6O4S

CAS No.
SMILES

O=C(NC1=CC=C(C#N)C=C1)CS(C2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HIV-1 inhibitor-23
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HY-146018
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