HIV-1 inhibitor-23
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability.
For research use only. We do not sell to patients.
- CAS No.: 2554622-28-3
- Formula: C30H26N6O4S
- Molecular Weight:566.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 24.9 nM (EC50) |
HIV-1 (K103N) 10.4 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
>221 μM
Compound: 12a
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 31735575] |
Chemical Information
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CAS No. 2554622-28-3
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Molecular Weight 566.63
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Formula C30H26N6O4S
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SMILES
O=C(NC1=CC=C(C#N)C=C1)CS(C2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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