2554622-28-3
Chemical Structure
HIV-1 inhibitor-23
- CAS No.: 2554622-28-3
- Formula:C30H26N6O4S
- Molecular Weight:566.63
IUPAC Name: (E)-N-(4-cyanophenyl)-2-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6,7-dimethoxyquinazolin-2-yl)sulfinyl)acetamide
InChIKey: BXNBZWBCCYYYDM-AATRIKPKSA-N
SMILES: O=C(NC1=CC=C(C#N)C=C1)CS(C2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)=O
Biological Activity: HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability[1].
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HIV-1 inhibitor-23 | HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability. | |||||||||||||||||||||
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Keywords
