2. Anti-infection
  3. Orthopoxvirus
  4. MPXV p37 protein-IN-1

MPXV p37 protein-IN-1 is a potent and orally active inhibitor of monkeypox virus (MPXV) p37 protein. MPXV p37 protein-IN-1 exhibits potent antivial activity against MPXV with an EC50 of 12.14 nM, with low cytotoxicity (CC50 = 304.63 μM). MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability in mice. MPXV p37 protein-IN-1 can be used for the research of anti-MPXV.

For research use only. We do not sell to patients.

MPXV p37 protein-IN-1

MPXV p37 protein-IN-1 Chemical Structure

CAS No. : 3096845-40-5

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MPXV p37 protein-IN-1 Related Antibodies

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Description

MPXV p37 protein-IN-1 is a potent and orally active inhibitor of monkeypox virus (MPXV) p37 protein. MPXV p37 protein-IN-1 exhibits potent antivial activity against MPXV with an EC50 of 12.14 nM, with low cytotoxicity (CC50 = 304.63 μM). MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability in mice. MPXV p37 protein-IN-1 can be used for the research of anti-MPXV[1].

IC50 & Target[1]

MPXV

12.14 nM (EC50)

In Vitro

MPXV p37 protein-IN-1 (compound C12) (1-10 μM, 48 h) demonstrates potent antiviral activity against MPXV in Vero cells[1].
MPXV p37 protein-IN-1 forms critical hydrogen bonds with residues TYR258 and SER292, which likely contribute to its enhanced binding affinity and antiviral potency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MPXV p37 protein-IN-1 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-∞ MRT0-∞ F
Mice[1] 1.5 mg/kg i.v. 2.18 h 0.083 h 1877 ng/mL 789 ng·h/mL 2.08 h /
Mice[1] 25 mg/kg p.o. 2.69 h 0.67 h 5860 ng/mL 21351 ng·h/mL 4.73 h 162 %
In Vivo

MPXV p37 protein-IN-1 (compound C12) (2000 mg/kg, p.o., single dose) is well tolerated in CD-1 mice[1].
MPXV p37 protein-IN-1 (100 mg/kg, p.o., daily for 14 days) is well tolerated in CD-1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice[1]
Dosage: 2000 mg/kg
Administration: p.o., single dose
Result: Showed no toxicity, abnormal weight gain, or gross pathological changes in major organs (lungs, intestines, kidneys, spleen).
Animal Model: CD-1 mice[1]
Dosage: 100 mg/kg
Administration: p.o., daily for 14 days
Result: Showed no abnormal weight changes, visible lesions, or histopathological alterations in mice.
Molecular Weight

375.39

Formula

C18H15F2N3O2S
CAS No.
SMILES

[H][C@@]12[C@@]3([H])C[C@@]3([H])[C@@]([C@](C(N4NC(NC5=CC(F)=C(F)C=C5)=S)=O)([H])[C@@]2([H])C4=O)([H])C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MPXV p37 protein-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPXV p37 protein-IN-13096845-40-5OrthopoxvirusMonkeypox virusTecovirimat derivativesP37 proteinInhibitorinhibitorinhibit

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