MPXV p37 protein-IN-1
MPXV p37 protein-IN-1 is a potent and orally active inhibitor of monkeypox virus (MPXV) p37 protein. MPXV p37 protein-IN-1 exhibits potent antivial activity against MPXV with an EC50 of 12.14 nM, with low cytotoxicity (CC50 = 304.63 μM). MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability in mice. MPXV p37 protein-IN-1 can be used for the research of anti-MPXV.
For research use only. We do not sell to patients.
- CAS No.: 3096845-40-5
- Formula: C18H15F2N3O2S
- Molecular Weight:375.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MPXV 12.14 nM (EC50) |
MPXV p37 protein-IN-1 (compound C12) (1-10 μM, 48 h) demonstrates potent antiviral activity against MPXV in Vero cells[1].
MPXV p37 protein-IN-1 forms critical hydrogen bonds with residues TYR258 and SER292, which likely contribute to its enhanced binding affinity and antiviral potency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MPXV p37 protein-IN-1 (100 mg/kg, p.o., daily for 14 days) is well tolerated in CD-1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 mice[1]
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Dosage:2000 mg/kg
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Administration:p.o., single dose
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Result:Showed no toxicity, abnormal weight gain, or gross pathological changes in major organs (lungs, intestines, kidneys, spleen).
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Animal Model:CD-1 mice[1]
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Dosage:100 mg/kg
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Administration:p.o., daily for 14 days
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Result:Showed no abnormal weight changes, visible lesions, or histopathological alterations in mice.
Chemical Information
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CAS No. 3096845-40-5
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Molecular Weight 375.39
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Formula C18H15F2N3O2S
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SMILES
[H][C@@]12[C@@]3([H])C[C@@]3([H])[C@@]([C@](C(N4NC(NC5=CC(F)=C(F)C=C5)=S)=O)([H])[C@@]2([H])C4=O)([H])C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPXV p37 protein-IN-1 Related Classifications
HY-180228 Related Classifications
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