1. Anti-infection
  2. HIV
    Reverse Transcriptase
  3. 3'-Azido-3'-deoxy-5-methylcytidine

3'-Azido-3'-deoxy-5-methylcytidine 

Cat. No.: HY-111640 Purity: 99.39%
Handling Instructions

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells.

For research use only. We do not sell to patients.

3'-Azido-3'-deoxy-5-methylcytidine Chemical Structure

3'-Azido-3'-deoxy-5-methylcytidine Chemical Structure

CAS No. : 1282040-14-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1].

IC50 & Target

HIV-1

0.06 μM (EC50, in PBM cells)

XMRV

43.5 μM (CC50, in MCF-7 cells)

Molecular Weight

282.26

Formula

C₁₀H₁₄N₆O₄

CAS No.

1282040-14-5

SMILES

OC[[email protected]@H]1[[email protected]@H](N=[N+]=[N-])[[email protected]]([[email protected]](N2C(N=C(C(C)=C2)N)=O)O1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5428 mL 17.7142 mL 35.4283 mL
5 mM 0.7086 mL 3.5428 mL 7.0857 mL
10 mM 0.3543 mL 1.7714 mL 3.5428 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
3'-Azido-3'-deoxy-5-methylcytidine
Cat. No.:
HY-111640
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