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Results for "

na+k

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/K+ ATPase (65) NKCC (11) Sodium Channel (4) AAK1 (2) Adrenergic Receptor (1) Akt (2) Antibiotic (2) Apoptosis (21) Aryl Hydrocarbon Receptor (1) Bacterial (6) Calcium Channel (2) CaMK (1) Caspase (1) CFTR (1) Chloride Channel (2) Cholinesterase (ChE) (2) Cyclin G-associated Kinase (GAK) (1) Drug Metabolite (4) EAAT (1) Elastase (1) Endogenous Metabolite (9) Environmental Pollutants (2) Fluorescent Dye (4) Fungal (2) GABA Receptor (5) Interleukin Related (1) Isotope-Labeled Compounds (6) JAK (1) LXR (1) mAChR (1) mTOR (1) NF-κB (3) NO Synthase (2) Nuclear Factor of activated T Cells (NFAT) (1) Parasite (2) PDHK (1) PDK-1 (1) Peptide-Drug Conjugates (PDCs) (1) Phosphodiesterase (PDE) (1) PI3K (1) PKC (1) Polo-like Kinase (PLK) (1) Potassium Channel (3) Prostaglandin Receptor (2) PROTACs (1) Proton Pump (6) Reactive Oxygen Species (ROS) (1) Reference Standards (20) RSV (2) Small Interfering RNA (siRNA) (1) STAT (1) TRP Channel (1)
By Research Areas:	Cancer (34) Cardiovascular Disease (36) Endocrinology (2) Infection (10) Inflammation/Immunology (10) Metabolic Disease (30) Neurological Disease (22)
Oligonucleotides:	Emulsifiers (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

108

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Sodium Channel NKCC Na+/HCO3- Cotransporter Na+/Ca2+ Exchanger Na+/K+ ATPase Na+/H+ Exchanger (NHE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1446

Oleic acid 60+ Cited Publications 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid	Environmental Pollutants Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

HY-Y0445A

Sodium dichloroacetate 25+ Cited Publications	PDK-1 NKCC PDHK Reactive Oxygen Species (ROS) Apoptosis	Cancer
Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na ⁺-K ⁺-2Cl ⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers .

HY-N1446B

Oleic acid sodium Maximum Cited Publications 64 Publications Verification Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Environmental Pollutants Apoptosis Na+/K+ ATPase	Metabolic Disease Cancer
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-N0877

Bufalin 5+ Cited Publications	Na+/K+ ATPase	Cancer
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-17468

Bumetanide 15+ Cited Publications Ro 10-6338; PF 1593	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-B0135

Furosemide 5+ Cited Publications	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-D0085

DiSC3(5) 10+ Cited Publications	Fluorescent Dye	Cancer
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-N2070

Acevaltrate 4 Publications Verification	Na+/K+ ATPase	Neurological Disease
Acevaltrate inhibits the *Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀*s of 22.8 μM and 42.3 μM, respectively .

HY-N1446S2

Oleic acid-13C18 1 Publications Verification 9-cis-Octadecenoic acid-¹³C₁₈; 9Z-Octadecenoic acid-¹³C₁₈	Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-12283

Rostafuroxin 2 Publications Verification PST 2238	Na+/K+ ATPase RSV	Cardiovascular Disease
Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na ⁺,K ⁺-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity .

HY-114252

Strophanthidin 1 Publications Verification	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N1381

Periplocin 5+ Cited Publications	Apoptosis	Inflammation/Immunology Cancer
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N1446S5

Oleic acid-d9 9-cis-Octadecenoic acid-d₉; 9Z-Octadecenoic acid-d₉	Apoptosis Na+/K+ ATPase Endogenous Metabolite	Metabolic Disease Cancer
Oleic acid-d₉ is deuterium labeled Oleic acid (HY-N1446). Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activato .

HY-100414

Soraprazan 2 Publications Verification BYK61359	Proton Pump	Metabolic Disease
Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (K_i=6.4 nM), with an IC₅₀ of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases .

HY-N1446S1

Oleic acid-d2 1 Publications Verification 9-cis-Octadecenoic acid-d₂; 9Z-Octadecenoic acid-d₂	Isotope-Labeled Compounds Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid-d₂) is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid ]. Oleic acid is a Na+/K+ ATPase activator .

HY-126415

Magnesium Lithospermate B 1 Publications Verification	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration .

HY-B0137

Prilocaine 1 Publications Verification	Na+/K+ ATPase	Neurological Disease
Prilocaine, an amino amide, is a *Na/K-ATPase* inhibitor. Prilocaine has neurotoxic effects .

HY-15718A

Istaroxime hydrochloride 5+ Cited Publications PST2744 hydrochloride	Na+/K+ ATPase Calcium Channel	Cardiovascular Disease
Istaroxime hydrochloride is a Na ⁺/K ⁺-ATPase inhibitor (IC₅₀=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

HY-P3278

Caloxin 2A1 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-17623C

(R)-Tegoprazan (R)-CJ-12420; (R)-RQ-00000004	Proton Pump	Metabolic Disease
(R)-Tegoprazan ((R)-CJ-12420; example 3), a benzimidazole derivative, is a potent kidney H ⁺/K ⁺-ATPase inhibitor with an IC₅₀ of 98 nM of canine kidney Na ⁺/K ⁺-ATPase. (R)-Tegoprazan has the potential for gastrointestinal diseases research .

HY-145154

Digoxigenin monodigitoxoside	Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease Metabolic Disease
Digoxigenin monodigitoxoside, a metabolite of Digoxin (HY-B1049), belongs to the class of cardenolides. Digoxigenin monodigitoxoside exerts its function by inhibiting *Na,K-ATPase*. Digoxigenin monodigitoxoside is used for the research of cardiovascular diseases such as congestive heart failure and cardiac arrhythmias .

HY-B0135A

Furosemide sodium 5+ Cited Publications	NKCC GABA Receptor	Cardiovascular Disease Metabolic Disease Cancer
Furosemide sodium is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide sodium is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-136933

Gitoxin	Na+/K+ ATPase	Cardiovascular Disease
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-N1446S

Oleic acid-13C 9-cis-Octadecenoic acid-¹³C; 9Z-Octadecenoic acid-¹³C	Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid- ¹³C is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-105416

Calphostin C 2 Publications Verification UCN-1028C	Antibiotic PKC Apoptosis	Metabolic Disease Cancer
Calphostin C is a highly selective PKC inhibitor (IC₅₀=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .

HY-15718

Istaroxime PST2744	Na+/K+ ATPase	Cardiovascular Disease
Istaroxime (PST2744) is a potent inhibitor of Na ⁺,K ⁺-ATPase with IC₅₀ of 0.11 μM.

HY-N6745

Citreoviridin	Na+/K+ ATPase Apoptosis	Infection Cardiovascular Disease
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-W754708

Ouabagenin	LXR Na+/K+ ATPase	Cardiovascular Disease
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 *(Na(+)/K(+)- transport ATPase)* inhibitor .

HY-B0135S

Furosemide-d5	NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl-?(NKCC) cotransporter, NKCC1 and NKCC2 .?Furosemide is also a GABAA?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-P3278A

Caloxin 2A1 TFA 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-N1446R

Oleic acid (Standard) 9-cis-Octadecenoic acid (Standard); 9Z-Octadecenoic acid (Standard)	Reference Standards Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S3

Oleic acid-d17 9-cis-Octadecenoic acid-d₁₇; 9Z-Octadecenoic acid-d₁₇	Isotope-Labeled Compounds Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid-d₁₇ is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-B1604

Chloroprocaine hydrochloride 2-Chloroprocaine hydrochloride	Na+/K+ ATPase	Neurological Disease
Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of *Na,K-ATPase* activity with an IC₅₀ of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve .

HY-P1565A

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

HY-W779529

Cerberin 2'-Acetylneriifolin	Na+/K+ ATPase	Cancer
Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities. It is cytotoxic to KB and NCI H187 cancer cells (IC₅₀s=1.92 and 1.24 μg/mL).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.

HY-17468R

Bumetanide (Standard) Ro 10-6338 (Standard); PF 1593 (Standard)	Reference Standards NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide (Standard) is the analytical standard of Bumetanide. This product is intended for research and analytical applications. Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC₅₀s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-B0135R

Furosemide (Standard) 5+ Cited Publications	Reference Standards NKCC GABA Receptor	Metabolic Disease Cancer
Furosemide (Standard) is the analytical standard of Furosemide. This product is intended for research and analytical applications. Furosemide is a potent and orally active inhibitor of Na ⁺/K ⁺/2Cl ^- (NKCC) cotransporter, NKCC1 and NKCC2 . Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-N1446S4

Oleic acid-13C-1 9-cis-Octadecenoic acid-¹³C-1; 9Z-Octadecenoic acid-¹³C-1	Isotope-Labeled Compounds Na+/K+ ATPase Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N6574

Marinobufogenin	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Metabolic Disease
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-N11690

Oleandrigenin	Na+/K+ ATPase	Cardiovascular Disease Cancer
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-B1604A

Chloroprocaine 2-Chloroprocaine	Na+/K+ ATPase	Neurological Disease
Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of *Na,K-ATPase* activity with an IC₅₀ of 13 mM. Chloroprocaine blocks peripheral nerve .

HY-137172

ETH 157	Sodium Channel	Others
ETH 157 is a neutral sodium-selective carrier. ETH 157 exhibits sufficient *Na ⁺/K ⁺ selectivity and enhanced Na ⁺/Ca ²⁺* selectivity, making it suitable for the detection of extracellular Na ⁺ activity .

HY-N1446BR

Oleic acid sodium (Standard) Sodium oleate (Standard); 9-cis-Octadecenoic acid sodium (Standard); 9Z-Octadecenoic acid sodium (Standard)	Reference Standards Na+/K+ ATPase Apoptosis	Metabolic Disease Cancer
Sodium oleate (Standard) is the analytical standard of Sodium oleate. This product is intended for research and analytical applications. Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

HY-B0137A

Prilocaine hydrochloride 1 Publications Verification	Na+/K+ ATPase	Neurological Disease
Prilocaine hydrochloride, an amino amide, is a *Na/K-ATPase* inhibitor. Prilocaine has neurotoxic effects .

HY-17468S

Bumetanide-d5	NKCC	Cardiovascular Disease
Bumetanide-d₅ is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with ?IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-124742

AR-HO47108	Na+/K+ ATPase	Others
AR-HO47108 is an orally active reversible Na+/K+ ATPase inhibitor. AR-HO47108 reversibly blocks the final step of gastric acid secretion by competitively binding to the potassium ion binding site of the Na+/K+ ATPase in the gastric wall cells. AR-HO47108 can be used for research on diseases related to excessive gastric acid secretion, such as peptic ulcers .

HY-105431

ASI-222	Na+/K+ ATPase	Cardiovascular Disease
ASI-222 is an aminosugar cardiac glycoside. ASI-222 can inhibit Na+/K+ ATPase and show positive inotropic effect. ASI-222 can be used for the research of cardiovascular disease .

HY-165407

Neltenexine	Elastase CFTR	Inflammation/Immunology
Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research .

HY-N2070R

Acevaltrate (Standard)	Reference Standards Na+/K+ ATPase	Neurological Disease
Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively .

Cat. No.	Product Name	Type

HY-D0085

DiSC3(5)

10+ Cited Publications

Fluorescent Dyes

DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-DY1021

DiSC3(5) (solution)

Fluorescent Dyes

DiSC3 (5) (solution) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3 (5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .
Solvent and concentration: DMSO: 1 mM
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-D0152

Tetramethylrhodamine-6-maleimide	Fluorescent Dyes
Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time .

HY-136894

Rhod-5N	Fluorescent Dyes
Rhod-5N is a cell-impermeant calcium-binding fluorescent dye composed of a BAPTA chelating group and a rhodamine fluorophore. Rhod-5N is often added to MOPS buffer to complex and indicate cation content. The selectivity of Rhod-5N for Cd ²⁺ is higher than other interfering cations ((Na+, K+, Mg ²⁺, Ca ²⁺, Zn ²⁺) except Pb ²⁺), and the detection limit is 3.1 μg/L .

Cat. No.	Product Name	Target	Research Area

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane Ca ²⁺-ATPase, respectively .

HY-P3278

Caloxin 2A1 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P3278A

Caloxin 2A1 TFA 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P1565A

Transdermal Peptide Disulfide TFA TD 1 Disulfide(peptide) TFA	Na+/K+ ATPase	Others
Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA) is a 11-amino acid peptide, binds to Na ⁺/K ⁺-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide Disulfide TFA can enhance the transdermal delivery of many macromolecules .

HY-P10773

CTP-amiodarone	Peptide-Drug Conjugates (PDCs) Calcium Channel Potassium Channel Sodium Channel Adrenergic Receptor	Cardiovascular Disease
CTP-amiodarone is a cell-penetrating conjugate of cardiomyocyte targeting peptide and Amiodarone (HY-14187). CTP-amiodarone exhibits antiarrhythmic efficacy through block of Na+, K+, Ca2+ channels and β-adrenergic receptors .

HY-P10228

S-Thanatin	Fungal Bacterial	Infection
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na ⁺/K ⁺) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1446

Oleic acid 60+ Cited Publications 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Na+/K+ ATPase Endogenous Metabolite Apoptosis
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

HY-N1446B

Oleic acid sodium Maximum Cited Publications 64 Publications Verification Sodium oleate; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Na+/K+ ATPase
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-N0877

Bufalin 5+ Cited Publications	Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Na+/K+ ATPase
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-N2070

Acevaltrate 4 Publications Verification	Iridoids Terpenoids Valeriana officinalis Linn. Plants Valerianaceae Source Classification	Na+/K+ ATPase
Acevaltrate inhibits the *Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀*s of 22.8 μM and 42.3 μM, respectively .

HY-114252

Strophanthidin 1 Publications Verification	Cardiovascular Disease Classification of Application Fields Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn. Source Classification	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N1381

Periplocin 5+ Cited Publications	Classification of Application Fields Asclepiadaceae Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Steroids Source Classification	Apoptosis
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-A0154

Deslanoside Deacetyllanatoside C; Desacetyllanatoside C	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Cardiacglycosides Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-126415

Magnesium Lithospermate B 1 Publications Verification	Cardiovascular Disease Neurological Disease Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenylpropanoids Plants Disease Research Fields Source Classification	Na+/K+ ATPase
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration .

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-N10424

Brazilein 2 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Food Research	Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC₅₀ of 500 μM against guinea pig Na ⁺,K ⁺-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .

HY-N6745

Citreoviridin	Cardiovascular Disease Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-W754708

Ouabagenin	Microorganisms Cardiacglycosides Endogenous metabolite Steroids Source Classification	LXR Na+/K+ ATPase
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 *(Na(+)/K(+)- transport ATPase)* inhibitor .

HY-N0885

Telocinobufagin 1 Publications Verification Telobufotoxin; Telocinobufogenin	Structural Classification Animals Classification of Application Fields Other Diseases Disease Research Fields Steroids Source Classification	JAK STAT mTOR PI3K Akt Polo-like Kinase (PLK) Na+/K+ ATPase Apoptosis Bacterial
Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na ⁺/K ⁺-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models .

HY-N1446R

Oleic acid (Standard) 9-cis-Octadecenoic acid (Standard); 9Z-Octadecenoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Na+/K+ ATPase Endogenous Metabolite Apoptosis
Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N1989

Bacoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Scrophulariaceae Metabolic Disease Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification	Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na ⁺/K ⁺-ATPase, Ca ²⁺-ATPase and Mg ²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .

HY-N6574

Marinobufogenin	Classification of Application Fields Neurological Disease Animals Metabolic Disease Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-N11690

Oleandrigenin	Apocynaceae Structural Classification Cardiacglycosides Nerium indicum Mill. Plants Steroids Source Classification	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-N1446BR

Oleic acid sodium (Standard) Sodium oleate (Standard); 9-cis-Octadecenoic acid sodium (Standard); 9Z-Octadecenoic acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Na+/K+ ATPase Apoptosis
Sodium oleate (Standard) is the analytical standard of Sodium oleate. This product is intended for research and analytical applications. Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium[1]. Sodium oleate is a Na+/K+ ATPase activator[2].

HY-N2070R

Acevaltrate (Standard)	Structural Classification Iridoids Terpenoids Valeriana officinalis Linn. Plants Valerianaceae Source Classification	Reference Standards Na+/K+ ATPase
Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively .

HY-N9149

Cryptanoside A	Apocynaceae Structural Classification Cardiacglycosides Cryptolepis buchananii Roem. et Schult. Plants Steroids Source Classification	Na+/K+ ATPase Akt NF-κB
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits *Na+/K+-ATPase* activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-118367

A 80915A	Microorganisms Antibiotics Source Classification	Na+/K+ ATPase Proton Pump
A 80915A is a seminaphthoquinone produced by Streptomyces and is a potent inhibitor of Na+/K+ ATPase involved in gastric acid secretion.

HY-N9456

14-Anhydrodigitoxigenin	Apocynaceae Structural Classification Acokanthera oblongifolia (Hochst.) Codd Cardiacglycosides Plants Steroids Source Classification	Na+/K+ ATPase
14-Anhydrodigitoxigenin is a cardenolides that can be isolated from the leaves of Acokanthera oblongifolia. 14-Anhydrodigitoxigenin is a Na ⁺/K ⁺-ATPase inhibitor .

HY-114252R

Strophanthidin (Standard)	Structural Classification Plants Brassicaceae Steroids Erysimum cheiranthoides Linn. Source Classification	Reference Standards Na+/K+ ATPase
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-13719R

Oleandrin (Standard) PBI-05204 (Standard)	Apocynaceae Structural Classification Nerium indicum Mill. Plants Steroids Source Classification	Reference Standards Na+/K+ ATPase
Oleandrin (Standard) is the analytical standard of Oleandrin. This product is intended for research and analytical applications. Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.

HY-N1217

Stauntosaponin A Stauntoside C	Apocynaceae Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Na+/K+ ATPase
Stauntosaponin A, a steroid glycoside, is a potent inhibitor of Na(+)/K(+)-ATPase with an IC₅₀ value of 21 nM. Stauntosaponin A can be isolated from Carnation and has potential anti-cancer research value .

HY-100801R

L-threo-3-Hydroxyaspartic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	EAAT Reference Standards
Prilocaine (hydrochloride) (Standard) is the analytical standard of Prilocaine (hydrochloride). This product is intended for research and analytical applications. Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-N10097

Chamigrenol	Cupressaceae Terpenoids Sesquiterpenes Plants Source Classification Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.	Na+/K+ ATPase Bacterial
Chamigrenol is a Na ⁺/K ⁺-ATPase inhibitor with an IC₅₀ value of 15.9 μg/mL. Chamigrenol shows strong inhibitory activities against Gram-positive and Gram-negative bacteria except Escherichia coli, with MIC values of 50 µg/mL .

HY-N10239

Aquastatin A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Disease Research Fields Source Classification	Others
Aquastatin A is an inhibitor of mammalian adenosine triphosphatases. Aquastatin A is isolated from a fungus identified as Fusarium aquaeductuum. Aquastatin A inhibits Na+/K(+)-ATPase with an IC₅₀ value of 7.1 μM, and H+/K(+)-ATPase with an apparent IC₅₀ value of 6.2 μM .

HY-136933R

Gitoxin (Standard)	Digitalis purpurea Linn. Structural Classification Scrophulariaceae Plants Steroids Source Classification	Reference Standards Na+/K+ ATPase
Gitoxin (Standard) is the analytical standard of Gitoxin. This product is intended for research and analytical applications. Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably .

HY-N0877R

Bufalin (Standard)	Structural Classification Animals Steroids Source Classification	Reference Standards Na+/K+ ATPase
Bufalin (Standard) is the analytical standard of Bufalin. This product is intended for research and analytical applications. Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-N13080

3-Oxo-bufalin	Microorganisms Steroids Source Classification	Others
3-Oxo-bufalin is an active compound that can be isolated from cultured toad liver tissue. 3-Oxo-bufalin can be produced through a metabolic pathway, and it is a metabolite of Bufalin (HY-N0877) catalyzed by the stereoselective 3β-dehydrogenase. Bufalin is a Na+/K+-ATPase inhibitor and has anti-tumor activity .

HY-A0154R

Deslanoside (Standard) Deacetyllanatoside C (Standard); Desacetyllanatoside C (Standard)	Digitalis purpurea Linn. Structural Classification Cardiacglycosides Scrophulariaceae Plants Steroids Source Classification	Reference Standards Na+/K+ ATPase Drug Metabolite
Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N1381R

Periplocin (Standard)	Structural Classification Asclepiadaceae Plants Periploca sepium Bunge Steroids Source Classification	Reference Standards Apoptosis
Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N9503

Carvacryl acetate	Structural Classification Natural Products Labiatae Launaea mucronata (Forssk.) Muschl. Plants Source Classification	TRP Channel Na+/K+ ATPase Parasite
Carvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na ⁺/K ⁺-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases .

HY-N16733

Deacetyltanghinin	Apocynaceae Structural Classification Cardiacglycosides Cerbera odollam Gaertn. Plants Steroids Source Classification	Na+/K+ ATPase Apoptosis Caspase Prostaglandin Receptor
Deacetyltanghinin is a selective inhibitor targeting Na ⁺/K ⁺ ATPase, acting through non-covalent binding but is highly cardiotoxic. Deacetyltanghinin inhibits Na ⁺/K ⁺ ATPase activity, induces cancer cell apoptosis (involving caspase pathway activation), and at the same time affect the TXA2-PGI2 balance in the rabbit heart. Deacetyltanghinin has significant anti-cancer activity and is mainly used in the research field of targeted therapy of malignant tumors such as breast cancer and lung cancer. At the same time, attention should be paid to the regulation of its cardiotoxicity .

HY-165443

Cassaine Nervocidine	Structural Classification Erythrophleum suaveolens (Guill. et Perr.) Brenan Terpenoids Diterpenoids Plants Fabaceae Source Classification	Na+/K+ ATPase
Cassaine (Nervocidine) is a Na ⁺/K ⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K ⁺, shows inhibition enhanced by Pi and antagonized by Na ⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias .

HY-N17413

(-)-γ-Cuparenol	Schisandra sphenanthera Rehd. et Wils Structural Classification Terpenoids Sesquiterpenes Plants Schisandraceae Source Classification	Bacterial Na+/K+ ATPase NF-κB Nuclear Factor of activated T Cells (NFAT)
(-)-γ-Cuparenol is a sesquiterpene compound with an IC₅₀ of 23.6 μg/mL against porcine Na ⁺/K ⁺-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candida albicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections .

Recombinant Proteins Recommended:

Species:	Human (5)
Tag:	GFP (1) His (3) Strep (3) GST (2) Flag (1) Fc (1)
Source:	HEK293 (2) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702909

	TBK1 Protein, Human (Active, sf9, GST) NAK	Human	Sf9 insect cells
	TBK1 Protein, Human (Active, sf9, GST) is the recombinant human-derived TBK1, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P7S1786

	NR4A1 Protein, Human GFRP1, HMR, NAK1	Human	E. coli

HY-P701763

	PXK Protein, Human (sf9, His, GST) PXK; PX domain-containing protein kinase-like protein; Modulator of Na; K-ATPase; MONaKA	Human	Sf9 insect cells
	PXK protein binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3, indicating a potential role in regulating neural electrical excitability and synaptic transmission. Despite lacking kinase activity, PXK's interaction with these subunits suggests a regulatory function in neural processes, emphasizing its potential contribution to the complex mechanisms governing brain neuronal function and communication. PXK Protein, Human (sf9, His, GST) is the recombinant human-derived PXK protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P702022

	SLC12A2 Protein, Human (HEK293, His, StrepⅡ, FLAG) SLC12A2; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2	Human	HEK293
	SLC12A2 Protein mediates electroneutral transport of chloride, potassium, and/or sodium ions across the membrane, crucial for regulating ionic balance and cell volume. SLC12A2 Protein, Human (HEK293, His, Strep, FLAG) is the recombinant human-derived SLC12A2 protein, expressed by HEK293 insect cells , with N-Strep, C-Flag, N-8*His labeled tag.

HY-P703077

	SLC12A2 Protein, Human (HEK293, His, StrepⅡ, GFP) SLC12A2; Solute carrier family 12 member 2; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2	Human	HEK293
	SLC12A2 Protein mediates electroneutral transport of chloride, potassium, and/or sodium ions across the membrane, crucial for regulating ionic balance and cell volume. SLC12A2 Protein, Human (HEK293, His, Strep, GFP) is the recombinant human-derived SLC12A2 protein, expressed by HEK293 , with N-Strep, N-EGF, N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-N1446S2

Oleic acid-13C18 1 Publications Verification
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S5

Oleic acid-d9
Oleic acid-d₉ is deuterium labeled Oleic acid (HY-N1446). Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activato .

HY-N1446S1

Oleic acid-d2 1 Publications Verification
Oleic acid-d₂) is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid ]. Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S

Oleic acid-13C
Oleic acid- ¹³C is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-B0135S

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl-?(NKCC) cotransporter, NKCC1 and NKCC2 .?Furosemide is also a GABAA?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-N1446S3

Oleic acid-d17
Oleic acid-d₁₇ is the deuterium labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-N1446S4

Oleic acid-13C-1
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .

HY-17468S

Bumetanide-d5
Bumetanide-d₅ is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with ?IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B0137AS

Prilocaine-d7 hydrochloride
Prilocaine-d₇ (hydrochloride) is deuterium labeled Prilocaine (hydrochloride). Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-W704786

Prilocaine Hydrochloride-d7
Prilocaine Hydrochloride-d₇ is the deuterium labeled Prilocaine hydrochloride (HY-B0137A). Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

Host:	Rabbit (9)
Reactivity:	Human (9) Rat (9) Mouse (9) Hamster (2)
Application:	IHC-P (5) ICC/IF (4) IF-Tissue (2) IP (1) IHC-F (2) WB (9) FC (2) ELISA (1)
Isotype:	IgG (9)
Conjugation:	Non-conjugated (9)
Clonality:	Polyclonal (1) Monoclonal (6) Recombinant (3)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80537

	Sodium Potassium ATPase Antibody A1A1; AT1A1; ATP1A1; Na+/K+ transporting; alpha 1 polypeptide; Na+/K+ ATPase 1; Na; K-ATPase 1; Sodium pump 1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Sodium Potassium ATPase Antibody is a non-conjugated and Rabbit origined IgG polyclonal antibody, targeting to alpha 1 Sodium Potassium ATPase. It can be used as a loading control antibody.

HY-P86381

	TBK1 Antibody (YA6073) TBK1; NAK; Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TBK1 Antibody (YA6073) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBK1.

HY-P86665

	Sodium Potassium ATPase Antibody (YA6357) ATP1A1; alpha 1 Sodium Potassium ATPase; A1A1; AT1A1; AT1A1_HUMAN; Atpa-1; ATPase Na+/K+transporting alpha 1 polypeptide; ATPase Na+/K+transporting subunit alpha 1; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na(+)/K(+) ATPase 1; Na(+)/K(+) ATPase alpha-1 subunit; Na+, K+ATPase alpha subunit; Na+/K+ATPase alpha 1 subunit; Na+/K+ATPase 1; Na, K ATPase alpha 1 subunit; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	Sodium Potassium ATPase Antibody (YA6357) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sodium Potassium ATPase.

HY-P86674

	TBK1 Antibody (YA6366) EC 2.7.11.1; FLJ11330; NAK; NF kappa B activating kinase; NF kB activating kinase; NF-kappa-B-activating kinase; Serine/threonine protein kinase TBK 1; Serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; TBK 1; TBK1_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human, Rat, Mouse
	TBK1 Antibody (YA6366) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBK1.

HY-P83742

	SLC12A1 Antibody (YA3471) BSC1 antibody; Bumetanide sensitive sodium 3 antibody; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 antibody; Kidney specific Na K Cl symporter antibody; Kidney-specific Na-K-Cl symporter antibody; MGC48843 antibody; Na K 2Cl cotransporter antibody; NKCC2 antibody; potassiumchloride cotransporter 2 antibody; S12A1_HUMAN antibody; Slc12a1 antibody; sodium potassium chloride cotransporter 2 antibody; solute carrier family 12 (sodium/potassium/chloride transporters) antibody; Solute carrier family 12 member 1 antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	SLC12A1 Antibody (YA3471) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC12A1.

HY-P81717

	NUR77 Antibody (YA1462) NR4A1; GFRP1; HMR; NAK1; Nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3	WB	Human, Mouse, Rat
	NUR77 Antibody (YA1462) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUR77.

HY-P81717A

	NUR77 Antibody (YA1462)(PBS only) NR4A1; GFRP1; HMR; NAK1; Nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3	WB	Human, Mouse, Rat
	NUR77 Antibody (YA1462) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUR77.

HY-P80910

	TBK1 Antibody (YA040) TBK1; NAK; Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1	WB	Human, Mouse, Rat, Hamster
	TBK1 Antibody (YA040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBK1.

HY-P80910A

	TBK1 Antibody (YA040)(PBS only) TBK1; NAK; Serine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1	WB	Human, Mouse, Rat, Hamster
	TBK1 Antibody (YA040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TBK1.

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Cat. No.	Product Name		Classification

HY-N1446

Oleic acid 60+ Cited Publications 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid		Emulsifiers
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

HY-RS14257

TBK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TBK1 Human Pre-designed siRNA Set A contains three designed siRNAs for TBK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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