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Cat. No.: HY-129236

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Hellebrin

Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways.

For research use only. We do not sell to patients.

CAS No.: 13289-18-4
Formula: C₃₆H₅₂O₁₅
Molecular Weight:724.79

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (271 KB)

Hellebrin Chemical Structure

CAS No.: 13289-18-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	16 nM Compound: hellebrin	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 20361780]
A549	IC₅₀	6 nM Compound: 3a	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23706005]
B16-F10	IC₅₀	>10000 nM Compound: hellebrin	Growth inhibition of mouse B16F10 cells after 72 hrs by MTT assay Growth inhibition of mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 20361780]
B16-F10	IC₅₀	>10000 nM Compound: 3a	Cytotoxicity against mouse B16F10 cells after 3 days by MTT assay Cytotoxicity against mouse B16F10 cells after 3 days by MTT assay	[PMID: 23706005]
CT26	IC₅₀	>10000 nM Compound: hellebrin	Growth inhibition of mouse CT26 cells after 72 hrs by MTT assay Growth inhibition of mouse CT26 cells after 72 hrs by MTT assay	[PMID: 20361780]
CT26.WT	IC₅₀	>10000 nM Compound: 3a	Cytotoxicity against mouse CT26.WT cells after 3 days by MTT assay Cytotoxicity against mouse CT26.WT cells after 3 days by MTT assay	[PMID: 23706005]
Hs 683	IC₅₀	7 nM Compound: hellebrin	Growth inhibition of human Hs683 cells after 72 hrs by MTT assay Growth inhibition of human Hs683 cells after 72 hrs by MTT assay	[PMID: 20361780]
Hs 683	IC₅₀	7 nM Compound: 3a	Cytotoxicity against human Hs683 cells after 3 days by MTT assay Cytotoxicity against human Hs683 cells after 3 days by MTT assay	[PMID: 23706005]
MCF7	IC₅₀	82 nM Compound: hellebrin	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 20361780]
MCF7	IC₅₀	44 nM Compound: 3a	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23706005]
PC-3	IC₅₀	11 nM Compound: 3a	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23706005]
SK-MEL-28	IC₅₀	68 nM Compound: 3a	Cytotoxicity against human SK-MEL-28 cells after 3 days by MTT assay Cytotoxicity against human SK-MEL-28 cells after 3 days by MTT assay	[PMID: 23706005]
U-373MG ATCC	IC₅₀	49 nM Compound: hellebrin	Growth inhibition of human U373 cells after 72 hrs by MTT assay Growth inhibition of human U373 cells after 72 hrs by MTT assay	[PMID: 20361780]
U-373MG ATCC	IC₅₀	36 nM Compound: 3a	Cytotoxicity against human U373 cells after 3 days by MTT assay Cytotoxicity against human U373 cells after 3 days by MTT assay	[PMID: 23706005]

Chemical Information

CAS No. 13289-18-4
Appearance Solid
Molecular Weight 724.79
Formula C₃₆H₅₂O₁₅
SMILES

O=C1C=CC([C@H]2CC[C@@]3([C@@]4(CC[C@@]5(C[C@H](CC[C@@]5([C@]4(CC[C@]23C)[H])C=O)O[C@]6([C@H](O)[C@H](O)[C@@]([H])(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](O7)CO)[C@@H](O6)C)[H])O)[H])O)=CO1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laetitia Moreno Y Banuls, et al. Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase. Mol Cancer. 2013 Apr 26:12:33. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Hellebrin

12(R)-HETE

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Cryptanoside A

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

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Bioz

Hellebrin

12(R)-HETE

Citreoviridin

Cryptanoside A

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Hellebrin Related Classifications

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