13289-18-4
Chemical Structure
Hellebrin
- CAS No.: 13289-18-4
- Formula:C36H52O15
- Molecular Weight:724.79
IUPAC Name: (3S,5S,8R,9S,10S,13R,14S,17R)-3-(((2R,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5,14-dihydroxy-13-methyl-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-10H-cyclopenta[a]phenanthrene-10-carbaldehyde
InChIKey: DCSLTSSPIJWEJN-YRFFWODSSA-N
SMILES: O=C1C=CC([C@H]2CC[C@@]3([C@@]4(CC[C@@]5(C[C@H](CC[C@@]5([C@]4(CC[C@]23C)[H])C=O)O[C@]6([C@H](O)[C@H](O)[C@@]([H])(O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](O7)CO)[C@@H](O6)C)[H])O)[H])O)=CO1
Biological Activity: Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways[1].
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Hellebrin | Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways. | |||||||||||||||||||||
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Keywords
