Oleandrigenin
Based on 1 Customer Validation
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities.
For research use only. We do not sell to patients.
- Purity: 98.42%
- CAS No.: 465-15-6
- Formula: C25H36O6
- Molecular Weight:432.55
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 12
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Viability of human A549 cells by MTT assay after 24 hrs
Viability of human A549 cells by MTT assay after 24 hrs
|
[PMID: 17595134] |
| A549 | IC50 |
0.36 μM
Compound: 12
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Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr
Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr
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[PMID: 17595134] |
| A549 | IC50 |
0.52 μM
Compound: 12
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Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr
Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr
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[PMID: 17595134] |
| BJ | IC50 |
0.1 μM
Compound: 2
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Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| BJ | IC50 |
0.1 μM
Compound: 2
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Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| CCRF-CEM | IC50 |
0.2 μM
Compound: 2
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Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| CCRF-CEM | IC50 |
0.2 μM
Compound: 2
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Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| HeLa | IC50 |
0.2 μM
Compound: 2
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| HeLa | IC50 |
0.2 μM
Compound: 2
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
|
[PMID: 32645647] |
| HepG2 | IC50 |
0.2 mM
Compound: 12
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Growth inhibition of human HepG2 cells
Growth inhibition of human HepG2 cells
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[PMID: 17595134] |
| MCF7 | IC50 |
0.8 μM
Compound: 2
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay
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[PMID: 31325787] |
| MCF7 | IC50 |
0.8 μM
Compound: 2
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
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[PMID: 32645647] |
| WI-38 | IC50 |
1.7 mM
Compound: 12
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Growth inhibition of human WI38 cells
Growth inhibition of human WI38 cells
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[PMID: 17595134] |
| WI-38 VA13 | IC50 |
0.16 mM
Compound: 12
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Growth inhibition of human VA13 cells
Growth inhibition of human VA13 cells
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[PMID: 17595134] |
Chemical Information
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CAS No. 465-15-6
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Appearance Solid
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Molecular Weight 432.55
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Formula C25H36O6
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Color White to off-white
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SMILES
O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86(15):10249-10262. [Content Brief]
[2]. Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oleandrigenin Related Classifications
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