Oleandrigenin

Cat. No.: HY-N11690 Purity: 98.42%: Data Sheet
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Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na⁺/K⁺-ATP-ase inhibiting and cytotoxic activities.

For research use only. We do not sell to patients.

Oleandrigenin Chemical Structure

CAS No. : 465-15-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na⁺/K⁺-ATP-ase inhibiting and cytotoxic activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.36 μM Compound: 12	Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr Inhibition of induction of ICAM1 expression in human A549 cells in presence of TNFalpha after 1 hr	[PMID: 17595134]
A549	IC₅₀	0.52 μM Compound: 12	Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr	[PMID: 17595134]
A549	IC₅₀	> 100 μM Compound: 12	Viability of human A549 cells by MTT assay after 24 hrs Viability of human A549 cells by MTT assay after 24 hrs	[PMID: 17595134]
BJ	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
BJ	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
CCRF-CEM	IC₅₀	0.2 μM Compound: 2	Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
CCRF-CEM	IC₅₀	0.2 μM Compound: 2	Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
HeLa	IC₅₀	0.2 μM Compound: 2	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
HeLa	IC₅₀	0.2 μM Compound: 2	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
HepG2	IC₅₀	0.2 mM Compound: 12	Growth inhibition of human HepG2 cells Growth inhibition of human HepG2 cells	[PMID: 17595134]
MCF7	IC₅₀	0.8 μM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay	[PMID: 31325787]
MCF7	IC₅₀	0.8 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32645647]
WI-38	IC₅₀	1.7 mM Compound: 12	Growth inhibition of human WI38 cells Growth inhibition of human WI38 cells	[PMID: 17595134]
WI-38 VA13	IC₅₀	0.16 mM Compound: 12	Growth inhibition of human VA13 cells Growth inhibition of human VA13 cells	[PMID: 17595134]

Molecular Weight

432.55

Formula

C₂₅H₃₆O₆

CAS No.

465-15-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 98.42%

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Data Sheet (271 KB) SDS (251 KB)

COA (254 KB) HNMR (277 KB) LCMS (329 KB)

Handling Instructions (2659 KB)

References

[1]. Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86(15):10249-10262. [Content Brief]

[2]. Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520. [Content Brief]

Oleandrigenin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleandrigenin465-15-6Na+/K+ ATPaseSodium potassium pumpCEMMCF7HeLaBJ cellsInhibitorinhibitorinhibit

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Oleandrigenin

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Oleandrigenin Related Antibodies

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Oleandrigenin Related Classifications

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The dilution calculator equation

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