1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase
  3. Chloroprocaine hydrochloride

Chloroprocaine hydrochloride (Synonyms: 2-Chloroprocaine hydrochloride)

Cat. No.: HY-B1604 Purity: 99.18%
Handling Instructions

Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve.

For research use only. We do not sell to patients.

Chloroprocaine hydrochloride Chemical Structure

Chloroprocaine hydrochloride Chemical Structure

CAS No. : 3858-89-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
25 mg USD 470 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve[1].

IC50 & Target

IC50: 13 mM (Na,K-ATPase)[1]

In Vivo

In mice, the intravenous LD50 of Chloroprocaine hydrochloride is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine hydrochloride is 950 mg/kg[1].

Molecular Weight

307.22

Formula

C₁₃H₂₀Cl₂N₂O₂

CAS No.

3858-89-7

SMILES

O=C(OCCN(CC)CC)C1=CC=C(N)C=C1Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (271.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2550 mL 16.2750 mL 32.5500 mL
5 mM 0.6510 mL 3.2550 mL 6.5100 mL
10 mM 0.3255 mL 1.6275 mL 3.2550 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Chloroprocaine2-ChloroprocaineNa+/K+ ATPaseSodium potassium pumpanestheticNa,K-ATPaseInhibitorinhibitorinhibit

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Product Name:
Chloroprocaine hydrochloride
Cat. No.:
HY-B1604
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