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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

serine protease inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ClpP (1) HCV Protease (3) Ser/Thr Protease (56) TMPRSS6 (1) Virus Protease (4) Amino Acid Derivatives (1) APC (2) Apoptosis (16) Bacterial (4) Beta-lactamase (1) Biochemical Assay Reagents (1) Caspase (2) Cathepsin (7) CDK (2) Complement System (1) COX (1) Dipeptidyl Peptidase (3) DNA/RNA Synthesis (3) Drug Intermediate (1) Elastase (1) Endogenous Metabolite (1) Factor Xa (9) FAP (2) Flavivirus (5) FOXO (1) Fungal (2) Furin (3) HCV (2) Hepcidin (1) HIV (1) HPV (1) HSV (1) Influenza Virus (3) Interleukin Related (3) Isotope-Labeled Compounds (2) MMP (1) mRNA (1) NF-κB (4) Notch (1) PAI-1 (7) Parasite (1) PDK-1 (1) Plasminogen/Plasmin (1) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (1) Proteasome (3) Reactive Oxygen Species (ROS) (1) Reference Standards (6) SARS-CoV (10) Sirtuin (1) STING (1) Thrombin (3) TNF Receptor (5) Toll-like Receptor (TLR) (1) Wnt (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (23) Infection (33) Inflammation/Immunology (24) Metabolic Disease (4) Neurological Disease (12)
Oligonucleotides:	CpG ODNs (1) mRNA (1)

105

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Serpin TMPRSS6 Ser/Thr Protease Enteropeptidase Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) ClpP Serine Racemase (SR) STK33 SRPK SHMT Microtubule‐associated serine/threonine kinase (MAST) Calpain Ser/Thr Kinase FASTK ASCT TSSK MASTL PASK/STK37

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0496

PMSF Maximum Cited Publications 146 Publications Verification Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride	Cathepsin Ser/Thr Protease	Neurological Disease
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible **serine proteases** inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .

HY-18234A

Leupeptin hemisulfate 60+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin hemisulfate potently inhibits* *serine, cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-12821

AEBSF hydrochloride 15+ Cited Publications	Thrombin Influenza Virus Ser/Thr Protease	Others
AEBSF hydrochloride is an irreversible inhibitor of **serine proteases**, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.

HY-B0190A

Nafamostat mesylate 15+ Cited Publications FUT-175	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic **serine protease** inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall .

HY-13512

Camostat mesylate 40+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Ser/Thr Protease SARS-CoV	Infection Inflammation/Immunology
Camostat mesylate (Camostat mesilate) is an orally active, synthetic **serine protease** inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-B2228

Proteinase, Aspergillus oryzae 1 Publications Verification	Biochemical Assay Reagents	Cancer
Proteinase, Aspergillus oryzae is a serine protease that hydrolyzes peptide bonds in protein substrates, preferring alkaline conditions (optimal pH 10.5). It efficiently degrades casein, poly-L-glutamic acid, and poly-L-lysine, with activity irreversibly inhibited by diisopropylfluorophosphate (DFP) and potato inhibitor. This enzyme catalyzes proteolysis via serine residues in its active site, finding applications in food processing (e.g., soy sauce fermentation), detergents, and leather industries due to its high yield in solid-state fermentation and cost-effective production.

HY-134616

Ulinastatin 4 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and **serine protease** inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

HY-W010128

6-(Dimethylamino)purine 6-Dimethylaminopurine; 6-DMAP	CDK DNA/RNA Synthesis Apoptosis	Cancer
6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis) .

HY-124379

TPCK 1 Publications Verification L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK	Ser/Thr Protease HPV Apoptosis PDK-1	Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .

HY-E70203

Recombinant aprotinin	Ser/Thr Protease	Cardiovascular Disease Inflammation/Immunology
Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes .

HY-116815

Lalistat 1 2 Publications Verification	Beta-lactamase Bacterial	Infection Neurological Disease
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC₅₀ of 68 nM. Lalistat 1 is a inhibitor of *immunoglobulin A1 protease* (IgA1P)** proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .

HY-160225

ISD sodium 4 Publications Verification	STING Interleukin Related	Inflammation/Immunology
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway .

HY-125959

Ucf-101 1 Publications Verification	Apoptosis	Cardiovascular Disease Neurological Disease
Ucf-101 is a selective and competitive inhibitor of *pro-apoptotic protease* Omi/HtrA2, with an IC₅₀ of 9.5 μM for His-Omi*. Ucf-101 exhibits very little activity against various other serine* proteases (IC₅₀>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .

HY-103351

Cathepsin G Inhibitor I	Cathepsin	Inflammation/Immunology
Cathepsin G Inhibitor I (Compound 7) is a potent, selective, reversible, competitive, non-peptidic Cathepsin G inhibitor (IC₅₀ = 53 nM; K_i = 63 nM). Cathepsin G Inhibitor I can be used in research related to immune disorders .

HY-33900

Dihydrofuran-3(2H)-one 3-Oxotetrahydrofuran	Ser/Thr Protease	Others
Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) is a cyclic ketone that can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin .

HY-16511

Upamostat 1 Publications Verification WX-671	PAI-1 Ser/Thr Protease	Infection Cancer
Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer .

HY-128570

FD-IN-1	Complement System	Inflammation/Immunology
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

HY-155482

NA-184 1 Publications Verification	Proteasome	Neurological Disease
NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC₅₀ of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC₅₀ of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin potently inhibits* *serine, cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-126034

3,4-Dichloroisocoumarin	Ser/Thr Protease Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
3,4-Dichloroisocoumarin is a potent *serine-protease* and SrLip inhibitor (K_i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms .

HY-10300

Narlaprevir 5 Publications Verification SCH 900518	HCV HCV Protease SARS-CoV	Infection
Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a K_i value of 6 nM and an EC₉₀ value of 40 nM . Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease . Narlaprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.3 μM .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	APC	Cardiovascular Disease
Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of APC. Activated Protein C (390-404), human inhibits APC-catalyzed inactivation of factor Va .

HY-100415

UKI-1 WX-UK1; UKI-1C	PAI-1 Ser/Thr Protease	Cancer
UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 0.41 μM. UKI-1 is also a low molecular weight **serine protease** inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .

HY-P4284

Z-GGF-CMK	Proteasome ClpP Bacterial	Infection
Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC₅₀ of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC₅₀ of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .

HY-137038

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride TLCK hydrochloride	Caspase Ser/Thr Protease FOXO	Cardiovascular Disease Cancer
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a **Serine protease** inhibitor with an IC₅₀ of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases .

HY-E70127

Serratiopeptidase Brasan; Dasen	Ser/Thr Protease COX Bacterial Prostaglandin Receptor Interleukin Related	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
Serratiopeptidase (Brasan; Dasen) is an orally active zinc-containing metalloprotease belonging to the serralysin family. Serratiopeptidase reduces the release of inflammatory mediators such as prostaglandins, thromboxanes and interleukins by inhibiting COX, thereby relieving pain, swelling and redness. Serratiopeptidase exhibits antibiofilm, mucolytic and wound-healing activities. As a serine protease, Serratiopeptidase has the ability to dissolve blood clots, fibrin and atherosclerotic plaques. Serratiopeptidase degrades amyloid fibrils and has potential anti-Alzheimer's effects. Serratiopeptidase shows cytotoxicity against colon cancer cells .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-U00346

TS-021 free base DPP-IV-IN-1	Dipeptidyl Peptidase	Metabolic Disease
DPP-IV-IN-1 is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), a highly specific **serine protease, with an IC₅₀** of 4.6 nM.

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-172242

Verducatib	Cathepsin Dipeptidyl Peptidase	Inflammation/Immunology
Verducatib (BI 1291583) is an orally active inhibitor of cathepsin C (also known as DPP1). Verducatib restores the protease-inhibitor balance by inhibiting the activation of neutrophil serine proteases, thereby alleviating pulmonary inflammation and regulating infection responses. Verducatib significantly reduces the risk (including severe exacerbations) and frequency of acute exacerbations in bronchiectasis (BE). Verducatib also improves lung function and quality of life, and shortens the duration of antibiotic use. The overall incidence of adverse events of Verducatib is comparable to that of placebo, with only slightly more mild-to-moderate cutaneous adverse events observed in the high-dose group, demonstrating promising clinical application potential .

HY-W014134

p-APMSF hydrochloride p-Amidinophenylmethylsulfonylfluoride hydrochloride	Ser/Thr Protease	Inflammation/Immunology
p-APMSF (p-Amidinophenylmethylsulfonylfluoride) hydrochloride is a serine protease and trypsin inhibitor with the characteristic of rapid onset of action. p-APMSF hydrochloride reduces the enzymatic hydrolysis of recombinant human G-CSF in rat pulmonary mucosa. Combined intratracheal treatment with p-APMSF hydrochloride and Laureth-9 significantly enhances its absorption efficiency in rat lungs. Following intranasal administration, p-APMSF hydrochloride does not increase the concentration of recombinant human G-CSF in rat plasma, nor does it alter the effect of G-CSF on inducing an increase in total white blood cell count .

HY-NP019

Agkistrodon halys batroxobin	Sirtuin Caspase Apoptosis	Neurological Disease
Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .

HY-120624

BMS-354326	Ser/Thr Protease	Inflammation/Immunology
BMS-354326 is a tryptase inhibitor with an IC₅₀ of 1.8 nM. BMS-354326 exhibits excellent selectivity against trypsin and most other related serine proteases. BMS-354326 can be used in the research of asthma and inflammatory diseases .

HY-130136A

TMPRSS6-IN-1 TFA	Ser/Thr Protease	Others
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-P5062A

DEC-RVRK-CMK TFA Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA	Furin	Infection
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (K_i=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .

HY-13512R

Camostat mesylate (Standard) Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)	Reference Standards Ser/Thr Protease SARS-CoV	Infection Inflammation/Immunology
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic **serine protease** inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-B0190

Nafamostat	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat, an anticoagulant, is a synthetic **serine protease** inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall .

HY-100217

DL-3-Indolylglycine	Amino Acid Derivatives Drug Intermediate	Cardiovascular Disease
DL-3-Indolylglycine is a compound intermediate and Amino acid derivative. DL-3-Indolylglycine can be used for the synthesis of serine protease inhibitors. DL-3-Indolylglycine is applicable to the research of thrombotic diseases .

HY-P4243A

Dansyl-Glu-Gly-Arg-Chloromethylketone TFA	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone TFA is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone TFA inhibits activated porcine factor IX .

HY-145349

FXIa-IN-6	Factor Xa	Cardiovascular Disease
FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (K_i = 0.3 nM).

HY-P5062

DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone	Furin	Infection
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (K_i=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .

HY-122592

Zifaxaban	Factor Xa	Cardiovascular Disease
Zifaxaban is an orally active, competitively and selective Factor Xa (FXa) inhibitor with an IC₅₀ of 11.1 nM for human FXa. Zifaxaban shows >10000-fold greater selectivity than other serine proteases. Zifaxaban can be used for the arterial and venous thrombosis research .

HY-14853

Darexaban YM150	Factor Xa Ser/Thr Protease	Cardiovascular Disease
Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC₅₀ of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects .

HY-130136

TMPRSS6-IN-1	Ser/Thr Protease	Others
TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .

HY-172090

MASP-2-IN-1	Ser/Thr Protease	Inflammation/Immunology
MASP-2-IN-1 (Compound 77) is a selective MASP-2 inhibitor with an IC₅₀ of 0.0114 μM, and an IC₅₀ of 13.2 μM against MASP-3. MASP-2-IN-1 inhibits the catalytic activity of MASP-2 in the lectin complement pathway. MASP-2-IN-1 is applicable to the research of immune diseases .

HY-B0190AR

Nafamostat mesylate (Standard) FUT-175 (Standard)	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease Reference Standards	Infection Cancer
Nafamostat (mesylate) (Standard) is the analytical standard of Nafamostat (mesylate). This product is intended for research and analytical applications. Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a *protease* inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-18234AR

Leupeptin hemisulfate (Standard)	Reference Standards Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

HY-151611

UAMC-00050	Ser/Thr Protease	Inflammation/Immunology
UAMC-00050 is a potent trypsin-like serine protease inhibitor. UAMC-00050 can be used in research of dry eye syndrome and ocular inflammation .

HY-126973

BI-1230	HCV Protease	Infection
BI-1230, a chemical probe, is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity .

Cat. No.	Product Name	Type

HY-B2228

Proteinase, Aspergillus oryzae

1 Publications Verification

Biochemical Assay Reagents

Proteinase, Aspergillus oryzae is a serine protease that hydrolyzes peptide bonds in protein substrates, preferring alkaline conditions (optimal pH 10.5). It efficiently degrades casein, poly-L-glutamic acid, and poly-L-lysine, with activity irreversibly inhibited by diisopropylfluorophosphate (DFP) and potato inhibitor. This enzyme catalyzes proteolysis via serine residues in its active site, finding applications in food processing (e.g., soy sauce fermentation), detergents, and leather industries due to its high yield in solid-state fermentation and cost-effective production.

HY-NP019

Agkistrodon halys batroxobin	Biochemical Assay Reagents
Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .

Cat. No.	Product Name	Target	Research Area

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin potently inhibits* *serine, cysteine* and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	APC	Cardiovascular Disease
Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of APC. Activated Protein C (390-404), human inhibits APC-catalyzed inactivation of factor Va .

HY-P4284

Z-GGF-CMK	Proteasome ClpP Bacterial	Infection
Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC₅₀ of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC₅₀ of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis .

HY-P5062A

DEC-RVRK-CMK TFA Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA	Furin	Infection
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (K_i=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .

HY-P4243A

Dansyl-Glu-Gly-Arg-Chloromethylketone TFA	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone TFA is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone TFA inhibits activated porcine factor IX .

HY-P5062

DEC-RVRK-CMK Decanoyl-Arg-Val-Arg-Lys-chloromethylketone	Furin	Infection
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (K_i=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a *protease* inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-137495

GGACK	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .

HY-137495A

GGACK hydrochloride	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .

HY-P1918A

Activated Protein C (390-404), human TFA	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992451

RLYB331 KY1066	Ser/Thr Protease Hepcidin Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease
RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6) . RLYB331 binds to the **serine protease active site of matriptase-2*, blocking protease* activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18234A

Leupeptin hemisulfate 60+ Cited Publications	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin hemisulfate potently inhibits* *serine, cysteine* and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-13512

Camostat mesylate 40+ Cited Publications Camostat mesilate; FOY305; FOY-S980	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Ser/Thr Protease SARS-CoV
Camostat mesylate (Camostat mesilate) is an orally active, synthetic **serine protease** inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-W010128

6-(Dimethylamino)purine 6-Dimethylaminopurine; 6-DMAP	Classification of Application Fields Other Diseases Disease Research Fields	CDK DNA/RNA Synthesis Apoptosis
6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis) .

HY-126034

3,4-Dichloroisocoumarin	Animals Coumarins Phenylpropanoids Source Classification	Ser/Thr Protease Apoptosis
3,4-Dichloroisocoumarin is a potent *serine-protease* and SrLip inhibitor (K_i for SrLip: 26.6 μM). 3,4-Dichloroisocoumarin is opened by serine proteases and then undergoes acylation with the enzyme, thereby inhibiting protease activity. 3,4-Dichloroisocoumarin can induce DNA fragmentation and Apoptosis. 3,4-Dichloroisocoumarin can be used in the research of multiple fields such as tumors, cardiovascular disease and enzyme catalytic mechanisms .

HY-13512R

Camostat mesylate (Standard) Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Ser/Thr Protease SARS-CoV
Camostat (mesylate) (Standard) is the analytical standard of Camostat (mesylate). This product is intended for research and analytical applications. Camostat mesylate (Camostat mesilate) is an orally active, synthetic **serine protease** inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .

HY-18234AR

Leupeptin hemisulfate (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Cathepsin Ser/Thr Protease Virus Protease
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

HY-N5185

Cyclothiazomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity .

HY-N4330

Rivulariapeptolides 1155	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1155 is a potent **serine protease** inhibitor with IC₅₀s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively .

HY-N4332

Rivulariapeptolides 1121	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1121 is a high potent and selective **serine protease** inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4331

Rivulariapeptolides 1185	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1185 is a high potent and selective **serine protease** inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4333

Rivulariapeptolides 988	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 988 is a high potent and selective **serine protease** inhibitor with IC₅₀ values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N15009

Kynapcin-13	Natural Products Microorganisms Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-13 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-13 has a little inhibitory effect on other serine proteases .

HY-N15010

Kynapcin-28	Microorganisms Antibiotics Other Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Kynapcin-28 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-28 has a little inhibitory effect on other serine proteases .

Cat. No.	Product Name	Chemical Structure

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-16511AS

(E)-Upamostat-d5
(E)-Upamostat-d₅ ((E)-WX-671-d₅) is the deuterium labeled (E)-Upamostat (HY-16511A). (E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor .

HY-100415S1

UKI-1-d8 acetate
UKI-1-d₈ acetate (WX-UK1-d₈ acetate) is the deuterium labeled UKI-1 acetate. UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 0.41 μM. UKI-1 is also a low molecular weight **serine protease** inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .

Cat. No.	Product Name		Classification

HY-160225

ISD sodium 4 Publications Verification		CpG ODNs
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway .

HY-174540

Human SERPINA1 mRNA		mRNA
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

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serine protease inhibitors

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