PfSUB1-IN-1
PfSUB1-IN-1 (compound 4c) is a plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) Inhibitor (IC50: 15 nM). PfSUB1 is an antimalarial target. PfSUB1-IN-1 inhibits the growth of a genetically modified P. falciparum line expressing reduced levels of PfSUB1 13-fold more efficiently compared to a wild-type parasite line.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C28H41BN4O7
- Molecular Weight:556.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
296 μM
Compound: 4c
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by resazurin dye based spectraMax M5 microplate reader analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by resazurin dye based spectraMax M5 microplate reader analysis
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[PMID: 39051854] |
Chemical Information
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Molecular Weight 556.46
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Formel C28H41BN4O7
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SMILES
O=C(N[C@@H](C1CCCC1)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC2)B(O)OC2=O)=O)=O)=O)C3=CC(C)=CC(C)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PfSUB1-IN-1 Related Classifications
HY-159479 Related Classifications
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