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Results for "

Ca2++channels

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Acyltransferase (1) Adenosine Receptor (5) Adrenergic Receptor (8) Akt (6) AMPK (4) Androgen Receptor (2) Apoptosis (10) Autophagy (8) Calcium Channel (142) CDK (1) Chloride Channel (4) Cholinesterase (ChE) (1) COX (4) Cytochrome P450 (2) DNA/RNA Synthesis (7) Dopamine Receptor (11) Drug Derivative (1) Endogenous Metabolite (8) Enterovirus (1) Environmental Pollutants (1) ERK (6) Estrogen Receptor/ERR (1) Ferroptosis (1) Fungal (2) GABA Receptor (4) Glutathione Peroxidase (1) HIV (4) iGluR (4) Insecticide (2) Interleukin Related (1) IRAK (6) Isotope-Labeled Compounds (17) JNK (6) Lactate Dehydrogenase (1) Leukotriene Receptor (1) mAChR (5) mGluR (2) Mineralocorticoid Receptor (2) Monoamine Oxidase (2) Na+/Ca2+ Exchanger (1) nAChR (2) Necroptosis (2) Neurokinin Receptor (1) NF-κB (6) Opioid Receptor (6) Parasite (13) Peptide-Drug Conjugates (PDCs) (1) PGE synthase (1) PKA (6) PKC (8) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (17) Reactive Oxygen Species (ROS) (2) Reference Standards (32) ROCK (6) Sodium Channel (22) TGF-beta/Smad (7) TNF Receptor (1) Toll-like Receptor (TLR) (6) TRP Channel (3) UGT (1) YAP (1)
By Research Areas:	Cancer (44) Cardiovascular Disease (59) Endocrinology (2) Infection (10) Inflammation/Immunology (24) Metabolic Disease (21) Neurological Disease (80)

By Targets:

5-HT Receptor (2)

Acyltransferase (1)

Adenosine Receptor (5)

Adrenergic Receptor (8)

Akt (6)

AMPK (4)

Androgen Receptor (2)

Apoptosis (10)

Autophagy (8)

Calcium Channel (142)

CDK (1)

Chloride Channel (4)

Cholinesterase (ChE) (1)

COX (4)

Cytochrome P450 (2)

DNA/RNA Synthesis (7)

Dopamine Receptor (11)

Drug Derivative (1)

Endogenous Metabolite (8)

Enterovirus (1)

Environmental Pollutants (1)

ERK (6)

Estrogen Receptor/ERR (1)

Ferroptosis (1)

Fungal (2)

GABA Receptor (4)

Glutathione Peroxidase (1)

HIV (4)

iGluR (4)

Insecticide (2)

Interleukin Related (1)

IRAK (6)

Isotope-Labeled Compounds (17)

JNK (6)

Lactate Dehydrogenase (1)

Leukotriene Receptor (1)

mAChR (5)

mGluR (2)

Mineralocorticoid Receptor (2)

Monoamine Oxidase (2)

Na+/Ca2+ Exchanger (1)

nAChR (2)

Necroptosis (2)

Neurokinin Receptor (1)

NF-κB (6)

Opioid Receptor (6)

Parasite (13)

Peptide-Drug Conjugates (PDCs) (1)

PGE synthase (1)

PKA (6)

PKC (8)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (17)

Reactive Oxygen Species (ROS) (2)

Reference Standards (32)

ROCK (6)

Sodium Channel (22)

TGF-beta/Smad (7)

TNF Receptor (1)

Toll-like Receptor (TLR) (6)

TRP Channel (3)

UGT (1)

YAP (1)

By Research Areas:

Cancer (44)

Cardiovascular Disease (59)

Endocrinology (2)

Infection (10)

Inflammation/Immunology (24)

Metabolic Disease (21)

Neurological Disease (80)

152

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0057

Gabapentin 10+ Cited Publications	Calcium Channel	Neurological Disease Cancer
Gabapentin is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain ^[2] .

HY-10341

Fasudil Hydrochloride Maximum Cited Publications 27 Publications Verification HA-1077 Hydrochloride; AT-877 Hydrochloride	ROCK Calcium Channel Autophagy PKA PKC HIV	Cancer
Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca ²⁺ channel antagonist and vasodilator ^[2] .

HY-12323

ISX-9 10+ Cited Publications Isoxazole 9	Calcium Channel	Neurological Disease
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca ²⁺ influx through both voltage-gated Ca ²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) ^[2] .

HY-10588

Bay K 8644 5+ Cited Publications (±)-Bay K 8644	Calcium Channel	Cardiovascular Disease Neurological Disease
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca ²⁺ channel agonist with an EC₅₀ of 17.3 nM. Bay K 8644 increases Ca ²⁺ influx through sarcolemmal Ca ²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects ^[2] .

HY-B0632

Diltiazem 5+ Cited Publications	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris ^[2] .

HY-15553A

Mibefradil dihydrochloride 10+ Cited Publications Ro 40-5967 dihydrochloride	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca ²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .

HY-Y0669

Pipecolic acid 2 Publications Verification	Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy ^[2].

HY-B1221

Flufenamic acid 5+ Cited Publications	COX AMPK Potassium Channel Chloride Channel Calcium Channel Parasite	Inflammation/Immunology
Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K ⁺ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-10341A

Fasudil Maximum Cited Publications 27 Publications Verification HA-1077; AT877	ROCK Calcium Channel Autophagy PKA PKC	Cancer
Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca ²⁺ channel antagonist and vasodilator ^[2] .

HY-15124

(S)-(-)-Bay-K-8644 5+ Cited Publications	Calcium Channel	Cardiovascular Disease
(S)-(-)-Bay-K-8644 is an agonist of L-type *Ca ²⁺ channel. (S)-(-)-Bay-K-8644 activates Ba ²⁺ currents (I_Ba) (EC₅₀*=32 nM).

HY-B0358

Flunarizine 5+ Cited Publications	Calcium Channel Sodium Channel Dopamine Receptor	Cardiovascular Disease Neurological Disease
Flunarizine is a potent dual *Na ⁺/Ca ²⁺ channel* (T-type) blocker. Flunarizine is a D₂ dopamine** receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects ^[2] .

HY-50722

NNC 55-0396 5 Publications Verification NNC 55-0396 dihydrochloride	Calcium Channel Cytochrome P450	Cardiovascular Disease Neurological Disease Cancer
NNC 55-0396 (NNC 55-0396 dihydrochloride) is a blood-brain-barrier-permeable T-type Ca ²⁺ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 selectively inhibits T-type Ca ²⁺ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma ^[2] .

HY-135897

Urolithin C 5 Publications Verification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation ^[2].

HY-17404

Cilnidipine 4 Publications Verification FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine *Ca ²⁺-channel* blocker on L and N-type Ca ²⁺ channel ^[2] . Antihypertensive effects .

HY-N0601

Ginsenoside Rf 1 Publications Verification Panaxoside Rf	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-B0358A

Flunarizine dihydrochloride 5+ Cited Publications	Calcium Channel Sodium Channel Dopamine Receptor	Cardiovascular Disease Neurological Disease
Flunarizine dihydrochloride is a potent dual *Na ⁺/Ca ²⁺ channel* (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects ^[2] .

HY-A0057A

Gabapentin hydrochloride 10+ Cited Publications	Calcium Channel	Neurological Disease Cancer
Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain ^[2] .

HY-12949

ML204 5+ Cited Publications	TRP Channel	Neurological Disease
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels ^[2].

HY-16216

Gabapentin enacarbil XP-13512	Calcium Channel	Neurological Disease
Gabapentin enacarbil (XP-13512) is a prodrug of Gabapentin (HY-A0057) designed to be absorbed throughout the intestine by high-capacity nutrient transporters. Gabapentin is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin enacarbil can be used for the study of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN) ^[2].

HY-B0340

Nefiracetam DM9384; DZL-221	nAChR iGluR mGluR PKC GABA Receptor Calcium Channel	Neurological Disease
Nefiracetam is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca ²⁺ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research ^[2] .

HY-N0252

Catharanthine 3 Publications Verification (+)-3,4-Didehydrocoronaridine	Calcium Channel	Cardiovascular Disease Neurological Disease Cancer
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity ^[2].

HY-N0126

Xanthone 3 Publications Verification	Environmental Pollutants Calcium Channel Monoamine Oxidase	Cardiovascular Disease Neurological Disease
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds ^[2].

HY-12498

GV-58 2 Publications Verification	Calcium Channel	Neurological Disease
GV-58 is a novel N- and P/Q-type calcium (Ca ²⁺) channel agonist with EC₅₀s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca ²⁺ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research ^[2] .

HY-16689

VU 0240551 1 Publications Verification	Potassium Channel	Others
VU 0240551 is a potent neuronal K-Cl cotransporter *KCC2* inhibitor (IC₅₀=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca ²⁺ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission ^[2].

HY-103307

FPL64176	Calcium Channel	Cardiovascular Disease
FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca ²⁺ channels with an EC₅₀ value of 16 nM ^[2].

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy ^[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-120597

SAK3	Calcium Channel	Neurological Disease
SAK3 is a potent T-type voltage-gated *Ca ²⁺ channels* (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca ²⁺ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice . SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity ^[2].

HY-15553

Mibefradil Ro 40-5967	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca ²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively .

HY-10341C

Fasudil dihydrochloride Maximum Cited Publications 27 Publications Verification HA-1077 dihydrochloride; AT-877 dihydrochloride	Calcium Channel ROCK PKA PKC Autophagy HIV	Cancer
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for *ROCK2* and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca ²⁺ channel antagonist and vasodilator ^[2] .

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Calcium Channel Fungal Parasite	Metabolic Disease
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) ^[2].

HY-41076

Ca2+ channel agonist 1 1 Publications Verification	Calcium Channel CDK	Neurological Disease
Ca ²⁺ channel agonist 1 is an agonist of N-type Ca ²⁺ channel and an inhibitor of *Cdk2, with EC₅₀*s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

HY-136909

SR33805	Calcium Channel	Cardiovascular Disease
SR33805 is a potent *Ca ²⁺ channel* antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca ²⁺ channels. SR33805 can be used for the research of acute or chronic failing hearts ^[2].

HY-U00212

Aranidipine MPC1304	Calcium Channel	Cardiovascular Disease
Aranidipine (MPC1304) is a *Ca ²⁺ channel* antagonist with potent and long-lasting antihypertensive effects.

HY-19721

ABT-639 3 Publications Verification	Calcium Channel	Neurological Disease
ABT-639 is a novel, peripherally acting, selective T-type *Ca ²⁺* channel blocker.

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent *Ca ²⁺ channel* blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia ^[2].

HY-126583

Nemadipine-A	Calcium Channel	Cancer
Nemadipine-A is a specific inhibitor of the EGL-19 L-type *Ca ²⁺ channel* . Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand ^[2].

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels ^[2] .

HY-12949A

ML204 hydrochloride 5+ Cited Publications	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels ^[2].

HY-10388A

TTA-Q6(isomer)	Calcium Channel	Others
TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca ²⁺ channel antagonist.

HY-Z8176

(Z)-Flunarizine	Sodium Channel	Neurological Disease
(Z)-Flunarizine is the (Z)-isomer of Flunarizine (HY-B0358). Flunarizine is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-121914

(2-Chlorophenyl)diphenylmethanol o-Chlorotriphenylmethanol	Calcium Channel	Neurological Disease
(2-Chlorophenyl)diphenylmethanol (UCL 1880) is an analog of the metabolite 2-chlorophen-diphenyl-methanol (CBM) of 2-chlorophenyl, The IC₅₀ for sI(AHP) inhibition is 1-2 μM. (2-chlorophenyl)diphenylmethanol is a weak Ca ²⁺ channel blocker .

HY-B0358AR

Flunarizine dihydrochloride (Standard)	Reference Standards Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine (dihydrochloride) (Standard) is the analytical standard of Flunarizine (dihydrochloride). This product is intended for research and analytical applications. Flunarizine dihydrochloride is a potent dual *Na ⁺/Ca ²⁺ channel* (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects ^[2] .

HY-115681

(2R/S)-6-PNG 1 Publications Verification 6-Prenylnaringenin; (±)-6-Prenylnaringenin	Calcium Channel	Neurological Disease
(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible **Ca_v3.2 T-type Ca ²⁺ channels (T-channels)** blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice .

HY-17404S

Cilnidipine-d7 FRC-8653-d₇	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel ^[2] . Antihypertensive effects .

HY-U00026

Semotiadil recemate fumarate	Calcium Channel	Cardiovascular Disease
Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective *Ca ²⁺ channel* antagonist.

HY-N15737

Fukinolic acid	Calcium Channel Enterovirus	Infection Cardiovascular Disease
Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a *receptor-operated Ca ²⁺ channels* (ROC)** inhibitor, suppressing extracellular Ca ²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca ²⁺ channels ^[2].

HY-101428

NS-638	Calcium Channel	Neurological Disease
NS-638 is a small nonpeptide molecule with *Ca ²⁺*-channel blocking properties. K ⁺-stimulated intracellular Ca ²⁺-elevation is blocked with an IC₅₀ value of 3.4 μM.

HY-W150752

Triphenylethylene	Estrogen Receptor/ERR Calcium Channel	Endocrinology
Triphenylethylene is an aromatic hydrocarbon that possesses weak estrogenic activity. Triphenylethylene antiestrogens relax duodenal intestinal muscle via a mechanism that involves inhibition of L-type Ca ²⁺ channels but not activation of K ⁺ channels .

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Cardiovascular Disease
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated *Ca2+ channels* . And (-)-Denudatin B has nonspecific antiplatelet action

HY-151452

Cav 3.2 inhibitor 3	Calcium Channel	Neurological Disease
Cav 3.2 inhibitor 3 (Compound 4) is a potent **Ca_v3.2 T-type Ca ²⁺ channel inhibitor with an IC₅₀** of 0.1534 μM, and has little binding affinity to D₂ receptors .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1,679 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,679 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

HY-L923

Ion Channel Lead-like Compound Library

9000 compounds

Ion channels are key proteins on the cell membrane that regulate the flow of ions across membranes. They participate in nearly all physiological processes, including nerve conduction, muscle contraction, heart rhythm, and pain perception. Abnormalities in their function can lead to various serious diseases such as arrhythmia, epilepsy, hypertension, neuropathic pain, and cancer. Therefore, ion channels are highly valuable drug targets—over 15% of approved drugs target ion channels currently, demonstrating their irreplaceable therapeutic value in cardiovascular, neurological, and analgesic fields.

MCE has collected a library of over 5,000 reported ion channel-related bioactive compounds targeting major sites such as Na+ channels, K+ channels, Ca2+ channels, GABA receptors, iGluRs, and others. Using AI models, these compounds are characterized through both 2D representations (molecular fingerprints, pharmacophores) and 3D representations (3D conformation) to screen for a collection of lead-like compounds highly similar to known active molecules. Additionally, an hERG channel prediction algorithm integrating XGB and ISE mapping strategy is employed to assess and exclude potential cardiotoxicity in the library.. This step significantly reduces safety risks in subsequent screenings, particularly for ion channel drug development related to cardiovascular systems (e.g., Nav1.5, Cav1.2), effectively minimizing failures due to hERG inhibition and serving as a valuable tool for ion channel drug screening.

Cat. No.	Product Name	Type

HY-Y0669

Pipecolic acid

2 Publications Verification

Biochemical Assay Reagents

Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent *Ca ²⁺ channel* blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia ^[2].

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels ^[2] .

HY-P5142

ω-Hexatoxin-Hv1a ω-ACTX-Hv1; ω-Atracotoxin-HV1	Insecticide Calcium Channel Apoptosis Necroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons ^[2] .

HY-P5869

Kurtoxin	Calcium Channel Sodium Channel	Neurological Disease
Kurtoxin is a selective Cav3 (T-type) voltage-gated *Ca ²⁺ channel* gating inhibitor with a K_d of 15 nM for Cav3.1 (α1G T-type) Ca ²⁺ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca ²⁺ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na ⁺ channel .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent *Ca ²⁺ channel* blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia ^[2].

HY-P10773

CTP-amiodarone	Peptide-Drug Conjugates (PDCs) Calcium Channel Potassium Channel Sodium Channel Adrenergic Receptor	Cardiovascular Disease
CTP-amiodarone is a cell-penetrating conjugate of cardiomyocyte targeting peptide and Amiodarone (HY-14187). CTP-amiodarone exhibits antiarrhythmic efficacy through block of Na+, K+, Ca2+ channels and β-adrenergic receptors .

HY-P5142A

ω-Hexatoxin-Hv1a TFA ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA	Insecticide Apoptosis Calcium Channel Necroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1584

Halofuginone Maximum Cited Publications 20 Publications Verification RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM ^[2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated *Ca ²⁺ channels*. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-135897

Urolithin C 5 Publications Verification	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation ^[2].

HY-N1584A

Halofuginone hydrobromide Maximum Cited Publications 20 Publications Verification RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM ^[2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated *Ca ²⁺ channels*. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0601

Ginsenoside Rf 1 Publications Verification Panaxoside Rf	Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Endogenous metabolite Araliaceae Source Classification	Calcium Channel Endogenous Metabolite
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-N0252

Catharanthine 3 Publications Verification (+)-3,4-Didehydrocoronaridine	Apocynaceae Cardiovascular Disease Alkaloids Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity ^[2].

HY-N0126

Xanthone 3 Publications Verification	Infection Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Calcium Channel Monoamine Oxidase
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds ^[2].

HY-B1671

(+)-Kavain	Structural Classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants Source Classification	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy ^[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Flavonoids Classification of Application Fields Flavones Metabolic Disease Plants Disease Research Fields Zingiberaceae	Calcium Channel
3,5,7,3’,4’-Pentamethoxyflavone is a Ca ²⁺ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases ^[2] .

HY-Y1667

2,6-Dibromophenol 1 Publications Verification	Monophenols Classification of Application Fields Marine natural products Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Calcium Channel Fungal Parasite
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca ²⁺ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC₅₀ of 2.78 mg/L for Daphnia magna and a 96 h EC₅₀ of 9.90 mg/L for algae (Scenedesmus quadricauda) ^[2].

HY-N1584R

Halofuginone (Standard) RU-19110 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM ^[2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584AR

Halofuginone hydrobromide (Standard) RU-19110 hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM ^[2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated *Ca ²⁺ channels*. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated *Ca ²⁺* channels, reduces the production of NO, TNF-α, IL-6 and *PGE2* in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases ^[2] .

HY-N0252A

Catharanthine Tartrate 3 Publications Verification (+)-3,4-Didehydrocoronaridine Tartrate	Apocynaceae Cardiovascular Disease Alkaloids Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification Cancer	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine Tartrate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity ^[2].

HY-N15737

Fukinolic acid	Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Calcium Channel Enterovirus
Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a *receptor-operated Ca ²⁺ channels* (ROC)** inhibitor, suppressing extracellular Ca ²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca ²⁺ channels ^[2].

HY-N3729

(-)-Denudatin B Denudatin B	Cardiovascular Disease Classification of Application Fields Piper betle L. Lignans Piperaceae Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated *Ca2+ channels* . And (-)-Denudatin B has nonspecific antiplatelet action

HY-Y1667R

2,6-Dibromophenol (Standard)	Structural Classification Monophenols Marine natural products Phenols Endogenous metabolite Source Classification	Calcium Channel Fungal Parasite Reference Standards
2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) ^[2].

HY-N0126R

Xanthone (Standard) 3 Publications Verification	Infection Classification of Application Fields Guttiferae Phenols Garcinia mangostana Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Monoamine Oxidase Calcium Channel
Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K ⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca ²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds ^[2].

HY-N7690R

3,5,7,3′,4′-Pentamethoxyflavone (Standard)	Structural Classification Flavonoids Flavones Plants Zingiberaceae	Reference Standards Calcium Channel
3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases ^[2] .

HY-N15735

Cimicifugic acid D 2-Caffeoylpiscidic acid	Ranunculaceae Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Calcium Channel
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca ²⁺ influx through *receptor-operated Ca ²⁺ channels* (ROC)** in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca ²⁺ channels (VDC) or K ⁺-induced contractions .

HY-N0601R

Ginsenoside Rf (Standard) Panaxoside Rf (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Endogenous metabolite Araliaceae Source Classification	Reference Standards Calcium Channel Endogenous Metabolite
Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

HY-135897R

Urolithin C (Standard)	Phenols Polyphenols Endogenous metabolite Source Classification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite
Urolithin C (Standard) is the analytical standard of Urolithin C. This product is intended for research and analytical applications. Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation ^[2].

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Cardiovascular Disease Apocynaceae Alkaloids Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine Sulfate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity ^[2].

HY-B1671R

(+)-Kavain (Standard)	Structural Classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants Source Classification	Reference Standards GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy ^[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N0252R

Catharanthine (Standard) (+)-3,4-Didehydrocoronaridine (Standard)	Apocynaceae Alkaloids Structural Classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Calcium Channel
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity ^[2].

HY-W105272R

2′-Deoxyadenosine 5′-monophosphate disodium (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM ^[2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

Cat. No.	Product Name	Chemical Structure

HY-N0215S14

L-Phenylalanine-15N,d8

L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals ^[2] .

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel ^[2] . Antihypertensive effects .

HY-B0632S

Diltiazem-d6
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris ^[2] .

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual *Na ⁺/Ca ²⁺ channel* (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects ^[2] .

HY-178251S

L-Phenylalanine-d

L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ²⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals ^[2] .

HY-B0561S4

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects ^[2] .

HY-B0380S1

Trimebutine-d5 fumarate

Trimebutine-d₅ fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) ^[2] .

HY-17404S1

Cilnidipine-d4
Cilnidipine-d₄ (FRC-8653-d₄) is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine *Ca ²⁺-channel* blocker on L and N-type Ca ²⁺ channel ^[2] . Antihypertensive effects .

HY-B0632S2

Diltiazem-d4
Diltiazem-d₄ is deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris ^[2] .

HY-W721517

Gabapentin-d10
Gabapentin-d₁₀ is the deuterium labeled Gabapentin (HY-A0057). Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain ^[2] .

HY-A0057AS2

Gabapentin-d4 hydrochloride
Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain ^[2] .

HY-W707161

4-Methyl-2-(1-piperidinyl)-quinoline-d10
4-Methyl-2-(1-piperidinyl)-quinoline-d₁₀ is the deuterium labeled ML204 (HY-12949). ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels ^[2].

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC₅₀s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier .

HY-B0549S

Flavoxate-d5

Flavoxate-d₅ is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions ^[2] .

HY-B0549AS

Flavoxate-d4 hydrochloride

Flavoxate-d₄ hydrochloride (Rec-7-0040-d₄) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions ^[2] .

HY-B0380S2

Trimebutine-d3 hydrochloride

Trimebutine-d₃ hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) ^[2] .

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