Monatepil maleate
Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia.
For research use only. We do not sell to patients.
- CAS No.: 103379-03-9
- Formula: C32H34FN3O5S
- Molecular Weight:591.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Monatepil maleate (30 mg/kg; p.o.; once daily for 6 weeks) inhibits ACAT activity and esterifies cholesterol content in high cholesterol diet monkeys[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8 weeks, Male japanese white rabbits (high cholesterol diet-fed)[1]
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Dosage:30 mg/kg
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Administration:P.o.; once daily for 9 weeks
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Result:Improved plasma lipid metabolism and reduced atherosclerotic lesions, decreased blood pressure.
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Animal Model:4-7 kg, 4-7 years monkeys (high cholesterol diet for 6 months)[2]
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Dosage:30 mg/kg
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Administration:P.o.; once daily for 6 weeks
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Result:Inhibited the increases of ACAT activity and esterified cholesterol content.
Chemical Information
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CAS No. 103379-03-9
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Molecular Weight 591.69
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Formula C32H34FN3O5S
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SMILES
OC(/C=C\C(O)=O)=O.FC(C=C1)=CC=C1N(CC2)CCN2CCCC(NC3C4=CC=CC=C4CSC5=CC=CC=C53)=O
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Synonyms
AJ-2615
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ikeno A, et al. Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits. Jpn J Pharmacol. 1998 Nov;78(3):303-12. [Content Brief]
[2]. Sumiya T, et al. Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys. Am J Hypertens. 1997 Jul;10(7 Pt 1):779-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Monatepil maleate Related Classifications
HY-106818A Related Classifications
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