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Cat. No.: HY-105415

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U 92032

U 92032 is a T-type Ca²⁺ channel antagonist. U 92032 inhibits Na⁺ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 142223-92-5
Formula: C₃₀H₃₅F₂N₃O₂
Molecular Weight:507.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

U 92032 Chemical Structure

CAS No.: 142223-92-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

U 92032 is a T-type Ca²⁺ channel antagonist. U 92032 inhibits Na⁺ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases^[1].

All Calcium Channel Isoforms :

All Sodium Channel Isoforms :

Chemical Information

CAS No. 142223-92-5
Molecular Weight 507.63
Formula C₃₀H₃₅F₂N₃O₂
SMILES

O=C1C(=CC(=CC=C1CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C(C)C)NCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Porcello DM, et al. Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I(T) and slow intrathalamic rhythms. J Neurophysiol. 2003 Jan;89(1):177-85. [Content Brief]

[2]. Avery RB, et al. Ca2+ channel antagonist U-92032 inhibits both T-type Ca2+ channels and Na+ channels in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1997 Feb;77(2):1023-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Protocols
Purity & Documentation
References

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U 92032

All Calcium Channel Isoforms

All Sodium Channel Isoforms