2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. Cholinesterase (ChE) Calcium Channel
  4. Multitarget AD-IN-4

Multitarget AD-IN-4 (compound IIIj) is a multitarget-directed ligand (MTDL), with the ability to simultaneously inhibit ChE enzymes (EeAChE IC50 = 0.157 μM, eqBuChE IC50 = 0.147 μM, hAChE IC50 = 1.551 μM, hBuChE IC50 = 2.152 μM), exhibit antioxidant activity, provide neuroprotection, and inhibit calcium channels (Ca2+ channel blockade: IC50 = 30.59 μM). Multitarget AD-IN-4 reverses Scopolamine (HY-N0296)-induced amnesia in a mouse model. Multitarget AD-IN-4 can be used for Alzheimer’s disease (AD) research.

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Multitarget AD-IN-4

Multitarget AD-IN-4 Chemical Structure

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Multitarget AD-IN-4 Related Antibodies

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AChE BChE

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Multitarget AD-IN-4 (compound IIIj) is a multitarget-directed ligand (MTDL), with the ability to simultaneously inhibit ChE enzymes (EeAChE IC50 = 0.157 μM, eqBuChE IC50 = 0.147 μM, hAChE IC50 = 1.551 μM, hBuChE IC50 = 2.152 μM), exhibit antioxidant activity, provide neuroprotection, and inhibit calcium channels (Ca2+ channel blockade: IC50 = 30.59 μM). Multitarget AD-IN-4 reverses Scopolamine (HY-N0296)-induced amnesia in a mouse model. Multitarget AD-IN-4 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

Calcium Channel

30.59 μM (IC50)

EeAChE

0.157 μM (IC50)

eqBCHE

0.147 μM (IC50)

hAChE

1.551 μM (IC50)

hBCHE

2.152 μM (IC50)

Molecular Weight

729.26

Formula

C39H45ClN6O6
SMILES

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=C(OCC3=CN(CCCNC4=C(CCCC5)C5=NC6=CC=C(Cl)C=C64)N=N3)C(OC)=C2)OCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multitarget AD-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multitarget AD-IN-4Cholinesterase (ChE)Calcium ChannelCa2+ channelsCa channelsmultitarget-directed ligandantioxidant activityScopolamine-induced amnesiaAlzheimer’s diseaseInhibitorinhibitorinhibit

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