Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 (Compound 4) is a potent Cav3.2 T-type Ca2+ channel inhibitor with an IC50 of 0.1534 μM, and has little binding affinity to D2 receptors.
For research use only. We do not sell to patients.
- CAS No.: 2878598-69-5
- Formula: C32H37N3O2
- Molecular Weight:495.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cav3.2 0.1534 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice, Cav3.2-dependent somatic and visceral pain model[1]
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Dosage:1, 3 and 10 mg/kg
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Administration:Intraperitoneal administration, once
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Result:Reduced the mechanical allodynia in the hindpaw and colonic pain/referred hyperalgesia following i.pl. and i.col. administrations of Na2S, a donor of H2S, respectively. Suppressed the i.pl. Na2S-induced paw allodynia in a dose-dependent manner, and the maximally effective doses were roughly estimated at 10 mg/kg.
Chemical Information
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CAS No. 2878598-69-5
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Molecular Weight 495.66
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Formula C32H37N3O2
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SMILES
O=C1N(C2CCN(C(CCCC3=CC=CC=C3)=O)CC2)C4=CC=CC=C4N1CCCCC5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cav 3.2 inhibitor 3 Related Classifications
HY-151452 Related Classifications
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