1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. CALP3

CALP3 

Cat. No.: HY-P1075 Purity: 99.27%
Handling Instructions

CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CALP3 Chemical Structure

CALP3 Chemical Structure

CAS No. : 261969-05-5

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2].

IC50 & Target

Ca2+

 

In Vitro

CALP3 (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1].
CALP3 (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50=50.97 μM) in cultured rat neocortical neurons. CALP3 causes dose-dependent inhibition of apoptosis (IC50=33.41 μM)[1].
CALP3 (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells[1].
CALP3 (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells[2].
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

881.07

Formula

C₄₄H₆₈N₁₀O₉

CAS No.

261969-05-5

Sequence

Val-Lys-Phe-Gly-Val-Gly-Phe-Lys

Sequence Shortening

VKFGVGFK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

CALP3CALP 3CALP-3Calcium ChannelCa2+ channelsCa channelsCa2+-likepeptideEFhandmotifsCalmodulinCaMpumpsAIDSischemiaCyclicInhibitorinhibitorinhibit

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