1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. CALP3 TFA

CALP3 TFA 

Cat. No.: HY-P1075A
Handling Instructions

CALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CALP3 TFA Chemical Structure

CALP3 TFA Chemical Structure

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Description

CALP3 TFA, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 TFA can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia[1][2].

IC50 & Target[1][2]

Ca2+

 

In Vitro

CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50=37.25 μM) in Fura-2-loaded neuronal cultures[1].
CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50=50.97 μM) in cultured rat neocortical neurons. CALP3 TFA causes dose-dependent inhibition of apoptosis (IC50=33.41 μM)[1].
CALP3 TFA (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells[1].
CALP3 TFA (100 μM; 15 min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells[2].
Cyclic-CALP3 is synthesized starting from Fmoc-Asp(PEG-PS)-OAl. Cyclic CALP3 is unable to inhibit Ca21 influx, and this peptide served as a negative control. Cyclic CALP3 does not inhibit the effect of glutamate[1].

Molecular Weight

995.10

Formula

C₄₆H₆₉F₃N₁₀O₁₁

Sequence

{Val}{Lys}{Phe}{Gly}{Val}{Gly}{Phe}{Lys}

Sequence Shortening

VKFGVGFK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CALP3CALP 3CALP-3Calcium ChannelCa2+ channelsCa channelsCa2+-likepeptideEFhandmotifsCalmodulinCaMpumpsAIDSischemiaCyclicInhibitorinhibitorinhibit

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CALP3 TFA
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HY-P1075A
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