Cav 3.2 inhibitor 2
Cav 3.2 inhibitor 2 is a Cav3.2 T-type Ca2+ channels inhibitor with an IC50 of 0.09339 μM under -80mV holding potential. Cav 3.2 inhibitor 2 potently suppresses T-channel-dependent somatic and visceral pain in mice. Cav 3.2 inhibitor 2 can be used for the research of intractable pain.
For research use only. We do not sell to patients.
- CAS No.: 2878598-92-4
- Formula: C32H37F2N3O
- Molecular Weight:517.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.09339 μM (-80mV Cav3.2), 1.109 μM (-110mV Cav3.2), 0.2167 μM (Cav3.1)[1]
Cav 3.2 inhibitor 2 (0.3 μM) shows a produced inhibition of Cav3.2 comparable to that of pimozide[1]. Cav 3.2 inhibitor 2 (1 and 10 μM; 90 min) shows a binding affinity to D2 receptor significantly less than pimozide[1]. Cav 3.2 inhibitor 2 (0.01-10 μM) inhibits T channels isoforms with IC50s of 0.09339, 1.109 and 0.2167 μM for -80mV Cav3.2, -110mV Cav3.2 and Cav3.1, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with Na2S intraplantar (i.pl.) administration[1]
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Dosage:1, 3 and 10 mg/kg
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Administration:Intraperitoneal injection; 1-10 mg/kg 30 min before i.pl. Na2S
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Result:Almost completely blocked the Na2S-induced colonic pain and referred hyperalgesia.
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Animal Model:Wild-type (WT) or Cav3.2-kockout (KO) C57BL/6 mice with oxaliplatin (OHP) injection[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; 10 mg/kg on day 7 after oxaliplatin treatment
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Result:Attenuated the oxaliplatin-induced allodynia in WT C57BL/6 mice, while showed no effect on KO mice.
Chemical Information
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CAS No. 2878598-92-4
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Molecular Weight 517.65
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Formula C32H37F2N3O
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SMILES
O=C1N(CCCCC2=CC=CC(F)=C2)C3=CC=CC=C3N1C4CCN(CCCCC5=CC=CC(F)=C5)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cav 3.2 inhibitor 2 Related Classifications
HY-151451 Related Classifications
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