Catharanthine Sulfate
Based on 3 publication(s) in Google Scholar
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity.
For research use only. We do not sell to patients.
- CAS No.: 153230-94-5
- Formula: C21H26N2O6S
- Molecular Weight:434.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Catharanthine Sulfate
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Customer Validation & Images
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Cell Proliferation/Viability Assay
All Calcium Channel Isoforms
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Biological Activity
Description
IC50 & Target
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L-type calcium channel |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HepG2 | IC50 |
>50 μM
Compound: Catharanthine sulfate
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Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 23708010] |
| HepG2 | IC50 |
>50 μM
Compound: Catharanthine sulfate
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Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 23708010] |
| K562 | IC50 |
>50 μM
Compound: Catharanthine sulfate
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Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 23708010] |
| MCF7 | IC50 |
>50 μM
Compound: Catharanthine sulfate
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 23708010] |
| MDA-MB-231 | IC50 |
>50 μM
Compound: Catharanthine sulfate
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Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 23708010] |
In Vivo
Catharanthine (40 mg/kg; ip; single dose) Sulfate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
Catharanthine (20 mg/kg; ip; for 14 consecutive days) Sulfate increases swimming time and decreases immobility time at D7 or D14 in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:13-week-old male SpragueDawley rats (300-350 g)[1]
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Dosage:0.5-20 mg/kg
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Administration:IV; single dose
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Result:Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
Chemical Information
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CAS No. 153230-94-5
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Molecular Weight 434.51
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Formula C21H26N2O6S
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SMILES
O=C([C@@]1(C2=C3C(C=CC=C4)=C4N2)[C@](C(CC)=C5)([H])[N@](CC3)C[C@]5([H])C1)OC.O=S(O)(O)=O
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Synonyms
(+)-3,4-Didehydrocoronaridine Sulfate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Signal
2025 Jul:131:111779. PMID: 40164418 -
PLoS One
UHPLC-QTOF-MS/MS-based metabolomic discovery of anticancer compounds in ethanolic extracts of Ficus hispida L. f. [Abstract]2026 Mar 3;21(3):e0343411. PMID: 41774720
Catharanthine Sulfate purchased from MedChemExpress. Usage Cited in: PLoS One. 2026 Mar 3;21(3):e0343411. [Abstract]
KKU-213A and KKU-055 after treatment with 0, 1, 10, 100, 500, and 1,000 μM of Catharanthine, Cianidanol, Procyanidine B2, and Quinic acid for 72 h.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
[1]. Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. [Content Brief]
[2]. Hugo R Arias, et al. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Catharanthine Sulfate Related Classifications
HY-N0252B Related Classifications
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