2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Catharanthine Sulfate

Catharanthine Sulfate  (Synonyms: (+)-3,4-Didehydrocoronaridine Sulfate)

Cat. No.: HY-N0252B
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Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity.

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CAS No. : 153230-94-5

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Other Forms of Catharanthine Sulfate:

Catharanthine Sulfate Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay

    Catharanthine Sulfate purchased from MedChemExpress. Usage Cited in: PLoS One. 2026 Mar 3;21(3):e0343411.

    KKU-213A and KKU-055 after treatment with 0, 1, 10, 100, 500, and 1,000 μM of Catharanthine, Cianidanol, Procyanidine B2, and Quinic acid for 72 h.

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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    Description

    Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Sulfate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity[1][2].

    IC50 & Target

    L-type calcium channel

     

    Cellular Effect
    Cell Line Type Value Description References
    HepG2 IC50
    > 50 μM
    Compound: Catharanthine sulfate
    Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23708010]
    HepG2 IC50
    > 50 μM
    Compound: Catharanthine sulfate
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23708010]
    K562 IC50
    > 50 μM
    Compound: Catharanthine sulfate
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23708010]
    MCF7 IC50
    > 50 μM
    Compound: Catharanthine sulfate
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23708010]
    MDA-MB-231 IC50
    > 50 μM
    Compound: Catharanthine sulfate
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTT assay
    		[PMID: 23708010]
    In Vivo

    Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) Sulfate evokes dose-dependent reductions in both BP and HR[1].
    Catharanthine (40 mg/kg; ip; single dose) Sulfate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h[1].
    Catharanthine (20 mg/kg; ip; for 14 consecutive days) Sulfate increases swimming time and decreases immobility time at D7 or D14 in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 13-week-old male SpragueDawley rats (300-350 g)[1]
    Dosage: 0.5-20 mg/kg
    Administration: IV; single dose
    Result: Evoked rapid, transient reductions in BP and HR (lasting ,2 minutes) at low doses (0.5–5 mg/kg), whereas at higher doses (10 and 20 mg/kg), the BP and HR reductions were sustained.
    Molecular Weight

    434.51

    Formula

    C21H26N2O6S
    CAS No.
    SMILES

    O=C([C@@]1(C2=C3C(C=CC=C4)=C4N2)[C@](C(CC)=C5)([H])[N@](CC3)C[C@]5([H])C1)OC.O=S(O)(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Catharanthine Sulfate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Catharanthine153230-94-5(+)-3,4-DidehydrocoronaridineCalcium ChannelCa2+ channelsCa channelsAnticancervincaalkaloidsvoltage-operated L-typeVOCCcardiomyocytesvascular smooth muscle cellsVSMCsblood pressureheart rateInhibitorinhibitorinhibit

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