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Cat. No.: HY-117055

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Ro 18-3981

Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca²⁺ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (V_h=-20 mV: IC₅₀=2.3 nM; V_h=-50 mV: IC₅₀=100 nM).

For research use only. We do not sell to patients.

CAS No.: 103295-92-7
Formula: C₂₄H₃₃N₃O₈S
Molecular Weight:523.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Ro 18-3981 Chemical Structure

CAS No.: 103295-92-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Calcium Channel Isoforms :

Chemical Information

CAS No. 103295-92-7
Molecular Weight 523.60
Formula C₂₄H₃₃N₃O₈S
SMILES

O=C(C1=C(C)NC(C)=C(C(CS(=O)(NC(C)C)=O)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Holck M, et al. Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential‐dependent blockade by Ro 18–3981[J]. British journal of pharmacology, 1987, 91(1): 61-67. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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