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Cat. No.: HY-19721

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ABT-639

Name: ABT-639
Brand: MedChemExpress
SKU: HY-19721
Price: 55.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

ABT-639 is a novel, peripherally acting, selective T-type Ca²⁺ channel blocker.

For research use only. We do not sell to patients.

Purity : 98.67%
CAS No.: 1235560-28-7
Formula: C₂₀H₂₀ClF₂N₃O₃S
Molecular Weight:455.91

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

ABT-639 Chemical Structure

CAS No.: 1235560-28-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Protocols (1)
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ABT-639 is a novel, peripherally acting, selective T-type Ca²⁺ channel blocker.

IC₅₀ & Target

T-type calcium channel

All Calcium Channel Isoforms :

In Vivo

ABT-639 blocks recombinant human T-type (Ca_v3.2) Ca²⁺ channels in a voltage-dependent fashion (IC₅₀=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC₅₀=8 μM). ABT-639 is significantly less active at other Ca²⁺ channels (e.g. Ca_v1.2 and Ca_v2.2) (IC₅₀>30 mM). ABT-639 has high oral bioavailability (%F=73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents. Following oral administration ABT-639 produces dose-dependent antinociception in a rat model of knee joint pain (ED₅₀=2 mg/kg, p.o.). ABT-639 (10-100 mg/kg, p.o.) also increases tactile allodynia thresholds in multiple models of neuropathic pain (e.g. spinal nerve ligation, CCI, and vincristine-induced, and capsaicin secondary hypersensitivity). ABT-639 does not attenuate hyperalgesia in inflammatory pain models induced by complete Freund’s adjuvant or carrageenan. At higher doses (e.g. 100-300 mg/kg) ABT-639 does not significantly alter hemodynamic or psychomotor function. The antinociceptive profile of ABT-639 provides novel insights into the role of peripheral T-type (Ca_v3.2) channels in chronic pain states^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1235560-28-7
Appearance Solid
Molecular Weight 455.91
Formula C₂₀H₂₀ClF₂N₃O₃S
Color White to off-white
SMILES

O=S(C1=CC(C(N2C[C@](CCC3)([H])N3CC2)=O)=C(Cl)C=C1F)(NC4=CC=CC=C4F)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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Journal Impact Factor

Nat Chem Biol

Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload. [Abstract]

2025 Aug;21(8):1238-1249. PMID: 39915626
iScience

Exploring CACNA1H as a potential candidate biomarker for calcific aortic valve disease. [Abstract]

2026 Apr 27;29(5):115616. PMID: 42088341
Eur Rev Med Pharmacol Sci

Inhibition of CACNA1H can alleviate endoplasmic reticulum stress and reduce myocardial cell apoptosis caused by myocardial infarction. [Abstract]

2020 Dec;24(24):12887-12895. PMID: 33378039
Biomed Pharmacother

Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress. [Abstract]

2019 Dec:120:109475. PMID: 31580970

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (21.93 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1934 mL

10.9671 mL

21.9342 mL

5 mM

0.4387 mL

2.1934 mL

4.3868 mL

10 mM

0.2193 mL

1.0967 mL

2.1934 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jarvis MF, et al. A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochem Pharmacol. 2014 Jun 15;89(4):536-44. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1934 mL	10.9671 mL	21.9342 mL	54.8354 mL
	5 mM	0.4387 mL	2.1934 mL	4.3868 mL	10.9671 mL
	10 mM	0.2193 mL	1.0967 mL	2.1934 mL	5.4835 mL
	15 mM	0.1462 mL	0.7311 mL	1.4623 mL	3.6557 mL
	20 mM	0.1097 mL	0.5484 mL	1.0967 mL	2.7418 mL

Bioz

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Protocols
Purity & Documentation
References

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ABT-639

Publications Citing Use of MedChemExpress (MCE) ABT-639

All Calcium Channel Isoforms