1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. SAK3

SAK3 

Cat. No.: HY-120597
Handling Instructions

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.

For research use only. We do not sell to patients.

SAK3 Chemical Structure

SAK3 Chemical Structure

CAS No. : 1256269-87-0

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Description

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].

In Vitro

SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Cav3.1 or Cav3.3-overexpressing neuro2A cells
Concentration: 0.1 nM
Incubation Time: 270 s
Result: Rapidly increased Ca2+ currents
In Vivo

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Animal Model:Cav3.1 knockout (KO) mice[1]
Dosage: 0.5 mg/kg
Administration: Administered p.o.
Result: Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
Molecular Weight

369.41

Formula

C₂₀H₂₃N₃O₄

CAS No.
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SAK3
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