1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. SAK3

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity.

For research use only. We do not sell to patients.

SAK3 Chemical Structure

SAK3 Chemical Structure

CAS No. : 1256269-87-0

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Based on 1 publication(s) in Google Scholar

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Description

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].

In Vitro

SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Cav3.1 or Cav3.3-overexpressing neuro2A cells
Concentration: 0.1 nM
Incubation Time: 270 s
Result: Rapidly increased Ca2+ currents
In Vivo

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Animal Model:Cav3.1 knockout (KO) mice[1]
Dosage: 0.5 mg/kg
Administration: Administered p.o.
Result: Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
Molecular Weight

369.41

Formula

C20H23N3O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)C1=C(C2(CC1=O)N3C=CC=C(C3=NC2=O)C)N4CCCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SAK3
Cat. No.:
HY-120597
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