2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Nemadipine-A

Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand.

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Nemadipine-A Chemical Structure

Nemadipine-A Chemical Structure

CAS No. : 54280-71-6

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Nemadipine-A Related Antibodies

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Description

Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].

In Vitro

Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (µM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants[1].
Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin[2]. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity[2]. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nemadipine-A Related Antibodies

Cell Viability Assay[2]

Cell Line: H1299 lung adenocarcinoma cells
Concentration: 0, 5, 10, 20, and 30 μM
Incubation Time: 8 hours
Result: H1299 cells were resistant to the apoptotic effects of TRAIL, but the co-administration of Nemadipine-A and TRAIL in these cells resulted in notably increased cytotoxicity in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: H1299 cells
Concentration: 20 μM
Incubation Time: 8 hours
Result: Co-treated with TRAIL and Nemadipine-A (T/N; 20 ng/mL and 20 μM respectively) induced cell death in H1299 cells.
Molecular Weight

419.34

Formula

C19H18F5NO4
CAS No.
SMILES

CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=C(C(F)=C(C(F)=C2F)F)F)C(OCC)=O
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Purity & Documentation
References
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Nemadipine-A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemadipine-A54280-71-6Calcium ChannelCa2+ channelsCa channelsEGL-19L-typeCa2+channelcalciumTRAILresistantcancerSensitizationH1299Inhibitorinhibitorinhibit

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