54280-71-6
54280-71-6
Chemical Structure
Nemadipine-A
- CAS No.: 54280-71-6
- Formula:C19H18F5NO4
- Molecular Weight:419.34
IUPAC Name: diethyl 2,6-dimethyl-4-(perfluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: QABNLWXKUCMDBP-UHFFFAOYSA-N
SMILES: CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=C(C(F)=C(C(F)=C2F)F)F)C(OCC)=O
Biological Activity: Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nemadipine-A | 98.87% | Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand. | ||||||||||||||||||||
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References
- [1]. Peter I Joyce, et al. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular. PLoS Genet. 2012;8(3):e1002602.degeneration [Content Brief]
- [2]. Seong Ho Park, et al. Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. Biomol Ther (Seoul). 2013 Jan;21(1):29-34. [Content Brief]
Keywords
