101 Results for "

Cytokine-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (101)

101 Results for "Cytokine-IN-1" in MCE Product Catalog:

Cytokine-IN-1
Cytokine-IN-1
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Cat. No.: HY-183533
CAS No.: 165806-16-6
Target:  

Interleukin Related TNF Receptor

Research Areas:  

Inflammation/Immunology

Cytokine-IN-1 is a trisubstituted imidazole-based cytokine inhibitory anti-inflammatory agent that inhibits IL-1, IL-6, IL-8 and TNF. Cytokine-IN-1 is used for the research of cytokine-mediated diseases [1].
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50
Oxidopamine hydrobromide
Oxidopamine hydrobromide
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50 Publications Verification
Cat. No.: HY-B1081A
CAS No.: 636-00-0
Synonyms: 6-HydroxydopamINe hydrobromide; 6-OHDA hydrobromide
Target:  

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:  

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome [1] .
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Oxidopamine hydrochloride
Oxidopamine hydrochloride
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50 Publications Verification
Cat. No.: HY-B1081
CAS No.: 28094-15-7
Synonyms: 6-HydroxydopamINe Hydrochloride
Target:  

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:  

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome [1] .
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8
QS-21-Api
QS-21-Api
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8 Cited Publications
Cat. No.: HY-101092
CAS No.: 141256-04-4
Purity:  99.67%
Synonyms: Stimulon
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NOD-like Receptor (NLR)

QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 [1] .
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[10]-Shogaol
[10]-Shogaol
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5 Cited Publications
Cat. No.: HY-N2434
CAS No.: 36752-54-2
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

COX Interleukin Related NF-κB Parasite

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis [1] .
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4
Muscone
Muscone
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4 Cited Publications
Cat. No.: HY-N0633
CAS No.: 541-91-3
Category:  

Cardiovascular Disease Animals Ketones, Aldehydes, Acids Disease Research Fields

Target:  

Environmental Pollutants TNF Receptor P-glycoprotein NF-κB NOD-like Receptor (NLR) Interleukin Related

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate [1].
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Manidipine
Manidipine
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3 Cited Publications
Cat. No.: HY-B0419
CAS No.: 89226-50-6
Target:  

Calcium Channel Interleukin Related

Research Areas:  

Cardiovascular Disease Neurological Disease Endocrinology

Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy [1] .
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Noreugenin
Noreugenin
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2 Cited Publications
Cat. No.: HY-N3029
CAS No.: 1013-69-0
Category:  

Natural Products  Rhododendron dauricum Linn. Plants Aloe arborescens Liliaceae Other Diseases Phenols Polyphenols Ericaceae Disease Research Fields

Target:  

Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase Necroptosis

Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits myeloperoxidase activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy [1].
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Araloside A
Araloside A
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2 Cited Publications
Cat. No.: HY-N2115
CAS No.: 7518-22-1
Synonyms: ChikusetsusaponIN IV
Category:  

Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields Araliaceae

Target:  

Renin Apoptosis Bcl-2 Family Interleukin Related

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis [1] .
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Gluconate Calcium
Gluconate Calcium
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1 Cited Publications
Cat. No.: HY-B1092
CAS No.: 299-28-5
Synonyms: Calcium D-gluconate; Gluconic acid hemicalcium salt
Category:  

Other Diseases Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Environmental Pollutants Endogenous Metabolite Interleukin Related NO Synthase ERK

Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury [1] .
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Oroxylin A-7-O-glucuronide
Oroxylin A-7-O-glucuronide
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1 Cited Publications
Cat. No.: HY-N2481
CAS No.: 36948-76-2
Synonyms: Oroxyloside; OroxylIN A-7-O-β-D-glucuronide
Category:  

Flavonoids Monophenols Neurological Disease Flavones Labiatae Phenols Plants Disease Research Fields Medicago truncatula Gaertn.

Target:  

Prolyl Endopeptidase (PREP) Drug Metabolite JNK PPAR NF-κB Interleukin Related

Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities [1] .
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Valencene
Valencene
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1 Cited Publications
Cat. No.: HY-N6636
CAS No.: 4630-07-3
Category:  

Terpenoids Sesquiterpenes Cyperaceae Cyperus rotundus L. Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model [1] .
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(S)-(+)-Carvone
(S)-(+)-Carvone
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1 Cited Publications
Cat. No.: HY-W013579
CAS No.: 2244-16-8
Synonyms: D-​Carvone
Category:  

Ketones, Aldehydes, Acids Gymnaster koraiensis Other Diseases Plants Umbelliferae Disease Research Fields

Target:  

Environmental Pollutants Apoptosis Caspase Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) SOD

(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis [1] .
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ML345
ML345
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1 Cited Publications
Cat. No.: HY-117878
CAS No.: 1632125-79-1
Purity:  99.37%
Target:  

IDE NOD-like Receptor (NLR) Interleukin Related

Research Areas:  

Inflammation/Immunology Endocrinology

ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage [1] .
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Handelin
Handelin
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1 Cited Publications
Cat. No.: HY-N2083
CAS No.: 62687-22-3
Category:  

Terpenoids Sesquiterpenes Genista vuralii A.Duran & Dural Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production .
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Schisantherin B
Schisantherin B
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1 Cited Publications
Cat. No.: HY-N0695
CAS No.: 58546-55-7
Synonyms: GomisIN-B; Wuweizi ester-B; SchisantherIN-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression [1] .
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MMK1
MMK1
0 Images
1 Cited Publications
Cat. No.: HY-P1117
CAS No.: 271246-66-3
Target:  

Formyl Peptide Receptor (FPR) Calcium Channel

Research Areas:  

Neurological Disease Inflammation/Immunology

MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity [1] .
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Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N5084
CAS No.: 205370-59-8
Category:  

Flavonoids Flavonones Other Diseases Phenols Polyphenols Plants Saxifragaceae Disease Research Fields Penthorum chinense Pursh

Target:  

TRP Channel HDAC p38 MAPK JNK ERK NF-κB TNF Receptor Interleukin Related

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8 + T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer [1] .
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Protectin D1
Protectin D1
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Cat. No.: HY-130413
CAS No.: 660430-03-5
Synonyms: NeuroprotectIN D1; NPD1
Category:  

Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Caspase Interleukin Related MicroRNA

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders [1] .
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Gluconate sodium
Gluconate sodium
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Cat. No.: HY-B1092A
CAS No.: 527-07-1
Synonyms: D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt
Category:  

other families Anti-aging Other Diseases Plants Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:  

Environmental Pollutants ERK NO Synthase Endogenous Metabolite Interleukin Related

Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury [1] .
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