Suciraslimab
Based on 1 Customer Validation
Suciraslimab (SM03) is an anti-human CD22 monoclonal antibody. Suciraslimab inhibits NLRP3 and ASC signaling. Suciraslimab suppresses cytokine (IL-1β, IL-12, IL-23) secretion and α4 integrin expression. Suciraslimab improves working memory and neuroinflammation. Suciraslimab isotype control product: Human IgG1 kappa, Isotype Control (HY-P99001).
For research use only. We do not sell to patients.
- Purity: 97.42%
- CAS No.: 2415439-63-1
- Molecular Weight:146.16 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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IL-23 |
IL-12 |
IL-1β |
Suciraslimab (0.1 μg/mL; overnight) inhibits the secretion of interleukin-1β (IL-1β) induced by Amyloid β (Aβ) in human monocyte-derived microglia-like cells (MDMi) and PBMC[1].
Suciraslimab (0.1 μg/mL; 4 h) enhances phagocytosis of FITC-Aβ by the human microglial cell line HMC-3 and the Phorbol 12-myristate 13-acetate (HY-18739)-differentiated human oligodendrocyte cell line MO3.13[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human CD22 transgenic mice (C57BL/6JGpt-Cd22em1Cin(hCD22)/Gpt), male, 6-9 months old, with intracerebroventricular injection of oligomeric Aβ to induce neuroinflammation[1]
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Dosage:15 mg/kg
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Administration:Intravenous injection; once a week
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Result:Restored spatial working memory.
Downregulated the expression of genes related to leukocyte migration and sialic acid binding in the brain.
Reduced the levels of chemokines such as CX3CL1, CCL24, and CCL4 in the cortex.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Flow Cytometry analysis of Raji cells labelling Siglec-2/CD22 (red) with Suciraslimab (anti-Siglec-2/CD22) (HY-P990781). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody. -
Immobilized Siglec-2/CD22 Protein, Human can bind Suciraslimab. The EC50 for this effect is 4.412 ng/mL.
Chemical Information
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CAS No. 2415439-63-1
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Appearance Liquid
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Molecular Weight 146.16 kDa
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Color Colorless to light yellow
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SMILES
[Suciraslimab]
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Synonyms
SM03
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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