Cat. No.: HY-N2434

[10]-Shogaol

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC₅₀ value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis.

For research use only. We do not sell to patients.

Purity: 99.66%
CAS No.: 36752-54-2
Formula: C₂₁H₃₂O₃
Molecular Weight:332.48

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

[10]-Shogaol Chemical Structure

CAS No.: 36752-54-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]

COX-2

7.5 μM (IC₅₀)

IL-1β

IL-6

All COX Isoforms :

All Interleukin Related Isoforms :

All NF-κB Isoforms :

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	ED₅₀	3.3 μM Compound: 12	Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]
PC-12	ED₅₀	1.8 μM Compound: 12	Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]

In Vitro

[10]-Shogaol (2-10 μM; 12-24 h) promotes the migration and emigration of normal human epidermal keratinocytes and dermal fibroblasts^[1].
[10]-Shogaol (2-10 μM) enhances the production of TGF-β, PDGF-αβ, and VEGF in both human normal epidermal keratinocytes and dermal fibroblasts^[1].
[10]-Shogaol inhibits COX-2 with an IC₅₀ of 7.5 μM^[2].
[10]-Shogaol (100 μM; 24 h) inhibits proliferation of Docetaxel (HY-B0011)-resistant prostate cancer cells (PC3R) and downregulates MRP1 and GSTπ protein expression ^[3].
[10]-Shogaol (1-200 μM; 24-72 h) shows larvicidal activity against Angiostrongylus cantonensis L5 larvae in a time- and dose-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

Human normal epidermal keratinocytes
Concentration:

2 μM, 10 μM
Incubation Time:

12 h, 24 h
Result:

Showed cell migration rates of 204.76% (12 h) and 236.0% (24 h) (at 2 μM).
Showed cell migration rates of 205.65% (12 h) and 250.44% (24 h) (at 10 μM).

Cell Migration Assay ^[1]

Cell Line:

Human dermal fibroblasts
Concentration:

2 μM, 10 μM
Incubation Time:

12 h, 24 h
Result:

Showed cell migration rates of 201.67% (12 h) and 246.06% (24 h) (at 2 μM).
Showed cell migration rates of 187.82% (12 h) and 237.92% (24 h) (at 10 μM).

In Vivo

[10]-Shogaol (30 mg/kg; p.o.,; 2 weeks) ameliorates DSS-induced colitis in mice by inhibiting inflammation, protecting intestinal barrier function, and regulating NF-κB signaling pathway^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/c mice (5-week-old) with DSS-induced colitis^[5]
Dosage:

30 mg/kg
Administration:

Oral administration (p.o.), 2 weeks
Result:

Significantly suppressed clinical symptoms of colitis, including weight loss and increased disease activity index; inhibited the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IFN-γ).
Downregulated the expression of iNOS and COX-2.
Inhibited phosphorylation of NF-κB.
Protected intestinal barrier function by increasing mucin expression and maintaining tight junction proteins (ZO-1 and occludin).

Chemical Information

CAS No. 36752-54-2
Appearance Liquid (Density: 0.996±0.06 g/cm³)
Molecular Weight 332.48
Formula C₂₁H₃₂O₃
Color Colorless to light yellow
SMILES

CCCCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

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Journal Impact Factor

Bioact Mater

Lipidomic analysis of plant-derived extracellular vesicles for guidance of potential anti-cancer therapy. [Abstract]

2024 Dec 10:46:82-96. PMID: 39737211
Food Chem

Conversion of gingerols to shogaols in ginger (Zingiber officinale roscoe) by puffing. [Abstract]

2024 Sep 15:452:139425. PMID: 38744128
Pharm Biol

Potential pharmacological quality control markers in the traditional Japanese medicine Hangeshashinto: identifying anti-inflammatory ingredients through a cell-based bioassay and multicomponent analysis. [Abstract]

2025 Dec;63(1):819-836. PMID: 41240012
Biosci Biotechnol Biochem

Role of phosphorylation and vanilloid ligand structure in ligand-dependent differential activations of transient receptor potential vanilloid 1. [Abstract]

2024 Oct 22;88(11):1316-1325. PMID: 39217101
University of Osaka

2025.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (300.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0077 mL

15.0385 mL

30.0770 mL

5 mM

0.6015 mL

3.0077 mL

6.0154 mL

10 mM

0.3008 mL

1.5038 mL

3.0077 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (7.52 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen CY, et al. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer. Int J Mol Sci. 2012;13(2):1762-77. [Content Brief]

[2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [Content Brief]

[3]. Liu CM, et al. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22(9). pii: E1477. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0077 mL	15.0385 mL	30.0770 mL	75.1925 mL
	5 mM	0.6015 mL	3.0077 mL	6.0154 mL	15.0385 mL
	10 mM	0.3008 mL	1.5038 mL	3.0077 mL	7.5192 mL
	15 mM	0.2005 mL	1.0026 mL	2.0051 mL	5.0128 mL
	20 mM	0.1504 mL	0.7519 mL	1.5038 mL	3.7596 mL
	25 mM	0.1203 mL	0.6015 mL	1.2031 mL	3.0077 mL
	30 mM	0.1003 mL	0.5013 mL	1.0026 mL	2.5064 mL
	40 mM	0.0752 mL	0.3760 mL	0.7519 mL	1.8798 mL
	50 mM	0.0602 mL	0.3008 mL	0.6015 mL	1.5038 mL
	60 mM	0.0501 mL	0.2506 mL	0.5013 mL	1.2532 mL
	80 mM	0.0376 mL	0.1880 mL	0.3760 mL	0.9399 mL
	100 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.7519 mL

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[10]-Shogaol

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Medicine Food Homology Compound Library

Phenols Library

Pyroptosis Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Antiparasitic Compound library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

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Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Cancer Natural Product Library

Antidepressant Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

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Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Cytokine Inhibitors Library

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Anti-Hematopathy Compound Library

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MCE Bioactive Compound Library

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

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Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) [10]-Shogaol

All COX Isoforms

All Interleukin Related Isoforms

All NF-κB Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

[10]-Shogaol Related Classifications

Cat. No.: HY-N2434