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Cat. No.: HY-N2434A

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(E)-[10]-Shogaol

(E)-[10]-Shogaol is a 5-HT_1A receptor partial agonist found in Zingiber officinale, with a K_i of 5.84 μM. (E)-[10]-Shogaol may be used in research on anxiety and depression.

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CAS No.: 104186-05-2
Formule: C₂₁H₃₂O₃
Masse moléculaire:332.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-[10]-Shogaol Chemical Structure

CAS No.: 104186-05-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

(E)-[10]-Shogaol is a 5-HT_1A receptor partial agonist found in Zingiber officinale, with a K_i of 5.84 μM. (E)-[10]-Shogaol may be used in research on anxiety and depression^[1].

IC₅₀ & Target

5-HT_1A Receptor

5.84 μM (Ki)

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	ED₅₀	3.3 μM Compound: 12	Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]

In Vitro

(E)-[10]-Shogaol exhibits a K_i of 5.84 μM against 5-HT_1A in HEK293 cells^[1].
(E)-[10]-Shogaol (10 μM) increases [³⁵S]-GTPγS binding^[1].
(E)-[10]-Shogaol crosses the Caco-2 monolayer by slow passive diffusion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 104186-05-2
Masse moléculaire 332.48
Formule C₂₁H₃₂O₃
SMILES

CCCCCCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Animals
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nievergelt A, et al. Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem. 2010 May 1;18(9):3345-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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(E)-[10]-Shogaol

Voir tous les produits spécifiques à Isoform 5-HT Receptor