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Cat. No.: HY-N2434A

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(E)-[10]-Shogaol

(E)-[10]-Shogaol is a 5-HT_1A receptor partial agonist found in Zingiber officinale, with a K_i of 5.84 μM. (E)-[10]-Shogaol may be used in research on anxiety and depression.

For research use only. We do not sell to patients.

CAS No.: 104186-05-2
Formula: C₂₁H₃₂O₃
Molecular Weight:332.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-[10]-Shogaol Chemical Structure

CAS No.: 104186-05-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

(E)-[10]-Shogaol is a 5-HT_1A receptor partial agonist found in Zingiber officinale, with a K_i of 5.84 μM. (E)-[10]-Shogaol may be used in research on anxiety and depression^[1].

IC₅₀ & Target

5-HT_1A Receptor

5.84 μM (Ki)

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	ED₅₀	3.3 μM Compound: 12	Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay	[PMID: 14980683]

In Vitro

(E)-[10]-Shogaol exhibits a K_i of 5.84 μM against 5-HT_1A in HEK293 cells^[1].
(E)-[10]-Shogaol (10 μM) increases [³⁵S]-GTPγS binding^[1].
(E)-[10]-Shogaol crosses the Caco-2 monolayer by slow passive diffusion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 104186-05-2
Molecular Weight 332.48
Formula C₂₁H₃₂O₃
SMILES

CCCCCCCCC/C=C/C(CCC1=CC(OC)=C(C=C1)O)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Animals
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nievergelt A, et al. Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem. 2010 May 1;18(9):3345-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(E)-[10]-Shogaol

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(E)-[10]-Shogaol Related Classifications

HY-N2434A Related Classifications