10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer
- Int J Mol Sci. 2012;13(2):1762-1777. doi: 10.3390/ijms13021762.
- 1. Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan.
- 2. Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan.
- 3. Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
- 4. Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
- 5. Department of Biology, University of California, Riverside, Riverside, CA 92521, USA.
- 6. Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
- 7. Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
- 8. Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
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