Cat. No.: HY-B1092

Gluconate Calcium

(Synonyms: Calcium D-gluconate; Gluconic acid hemicalcium salt)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 299-28-5
Formula: C₆H₁₂O₇.1/2Ca
Molecular Weight:216.20

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Gluconate Calcium Chemical Structure

CAS No.: 299-28-5

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All NO Synthase Isoforms :

All Interleukin Related Isoforms :

All Endogenous Metabolite Isoforms :

All ERK Isoforms :

In Vitro

Gluconate Calcium (0.5-3 mM; 5 min) inhibits thrombin-induced arachidonic acid peroxidation and superoxide anion production in platelets, reduces platelet protein oxidation/nitration, and decreases carbonyl group generation, thiol oxidation, and nitrotyrosine formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Gluconate Calcium (50 g/kg of basal diet; orally; 33 weeks) increases the cecal butyrate concentration in rats and reduces the tumor incidence and the average number of tumors in rats with induced colorectal cancer^[2].
Gluconate Calcium (50 mg/kg body weight; once a day for 5 weeks) regulates the changes in hematological parameters induced by Dimethylhydrazine (HY-W460407) in mice, reduces the levels of lipid peroxidation and nitric oxide (NO) in colon tissues, and improves the pathological changes of colon tissues^[3].
Gluconate sodium (2500 ppm; in diet; p.o.; 15 days) increases the average daily gain of weaned piglets, reduces the feed-to-gain ratio, alleviates the intestinal injury induced by recombinant Escherichia coli, and improves the intestinal morphology^[4].
Gluconate sodium (Calcium gluconate; 50 mg/kg; p.o.; 84 days) alleviates the symptoms of osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats, and inhibits joint stiffness and cartilage damage^[5].
Gluconate sodium (Calcium gluconate; 12.5-50 mg/kg; i.p.; 30 min after modeling) alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice, and inhibits the infiltration of inflammatory cells and the release of inflammatory cytokines^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 299-28-5
Appearance Solid
Molecular Weight 216.20
Formula C₆H₁₂O₇.1/2Ca
Color White to off-white
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O.[1/2Ca]
Synonyms

Calcium D-gluconate; Gluconic acid hemicalcium salt
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Plant Soil

2026 Apr 24.

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (92.51 mM; Need ultrasonic)

DMSO : 1 mg/mL (4.63 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6253 mL

23.1267 mL

46.2535 mL

5 mM

0.9251 mL

4.6253 mL

9.2507 mL

10 mM

0.4625 mL

2.3127 mL

4.6253 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saluk-Juszczak J. A comparative study of antioxidative activity of calcium-D-glucarate, sodium-D-gluconate and D-glucono-1,4-lactone in a human blood platelet model. Platelets. 2010;21(8):632-40. [Content Brief]

[2]. Kameue C, et al. Dietary sodium gluconate protects rats from large bowel cancer by stimulating butyrate production. J Nutr. 2004 Apr;134(4):940-4. [Content Brief]

[3]. Saleem TH, et al. Possible Protective Effects of Quercetin and Sodium Gluconate Against Colon Cancer Induction by Dimethylhydrazine in Mice. Asian Pac J Cancer Prev. 2015;16(14):5823-8. [Content Brief]

[4]. Zhang Y, et al. Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain. BMC Vet Res. 2022 Aug 6;18(1):303. [Content Brief]

[5]. Kang SJ, et al. Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats. J Orthop Surg Res. 2014 Mar 7;9(1):14. [Content Brief]

[6]. Liu L, et al. Effects of calcium gluconate on lipopolysaccharide-induced acute lung injury in mice. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2931-2935. [Content Brief]

[7]. R Touir, et al. Sodium gluconate as corrosion and scale inhibitor of ordinary steel in simulated cooling water. Corrosion Science Volume 50, Issue 6, June 2008, Pages 1530-1537

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	4.6253 mL	23.1267 mL	46.2535 mL	115.6337 mL
H₂O	5 mM	0.9251 mL	4.6253 mL	9.2507 mL	23.1267 mL
	10 mM	0.4625 mL	2.3127 mL	4.6253 mL	11.5634 mL
	15 mM	0.3084 mL	1.5418 mL	3.0836 mL	7.7089 mL
	20 mM	0.2313 mL	1.1563 mL	2.3127 mL	5.7817 mL
	25 mM	0.1850 mL	0.9251 mL	1.8501 mL	4.6253 mL
	30 mM	0.1542 mL	0.7709 mL	1.5418 mL	3.8545 mL
	40 mM	0.1156 mL	0.5782 mL	1.1563 mL	2.8908 mL
	50 mM	0.0925 mL	0.4625 mL	0.9251 mL	2.3127 mL
	60 mM	0.0771 mL	0.3854 mL	0.7709 mL	1.9272 mL
	80 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4454 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Gluconate Calcium

1 Cited Publications

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Gluconate Calcium

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Publications Citing Use of MedChemExpress (MCE) Gluconate Calcium

All NO Synthase Isoforms

All Interleukin Related Isoforms

All Endogenous Metabolite Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation