N,N'-Dimethylhydrazine dihydrochloride
Based on 1 Customer Validation
N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 306-37-6
- Formula: C2H10Cl2N2
- Molecular Weight:133.02
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
N,N'-Dimethylhydrazine (DMH) (20 mg/kg; sc; once weekly, 24 wk) can induce colon cancer in ICR mice[1].
N,N'-Dimethylhydrazine (20 mg/kg ; sc; 20 wk) induces intraperitoneal intestinal tumors in rats, an effect that is potently inhibited by Lactobacillus acidophilus. Mice that consumed a beef diet that mimicked a "Western" diet had a higher incidence of colon cancer than grain-fed mice (83% vs. 31%, respectively)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mouse[1]
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Dosage:20 mg/kg
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Administration:sc; once weekly for 24 weeks; sacrificed mouse after between 23 and 33 weeks.
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Result:Induced colon cancer in ICR mice.
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Animal Model:Male inbred F344 rats[1]
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Dosage:20 mg, 4 mg/mL dissolved in normal saline containing 1.5% EDTA (pH 6.4 and filter sterilized)
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Administration:sc; weekly for 20 or 35 weeks
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Result:Produced a higher incidence of adenocarcinomas in the small and large intestines of animals that were consuming the meat diet.
Chemical Information
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CAS No. 306-37-6
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Appearance Solid
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Molecular Weight 133.02
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Formula C2H10Cl2N2
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Color White to off-white
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SMILES
CNNC.[H]Cl.[H]Cl
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Synonyms
1,2-Dimethylhydrazine dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 175 mg/mL (1315.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
[1]. Nakamura S, et al. Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride. Acta Pathol Jpn. 1982 May;32(3):473-81. [Content Brief]
[2]. Goldin BR, et al. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J Natl Cancer Inst. 1980 Feb;64(2):263-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.5177 mL | 37.5883 mL | 75.1767 mL | 187.9417 mL |
| 5 mM | 1.5035 mL | 7.5177 mL | 15.0353 mL | 37.5883 mL | |
| 10 mM | 0.7518 mL | 3.7588 mL | 7.5177 mL | 18.7942 mL | |
| 15 mM | 0.5012 mL | 2.5059 mL | 5.0118 mL | 12.5294 mL | |
| 20 mM | 0.3759 mL | 1.8794 mL | 3.7588 mL | 9.3971 mL | |
| 25 mM | 0.3007 mL | 1.5035 mL | 3.0071 mL | 7.5177 mL | |
| 30 mM | 0.2506 mL | 1.2529 mL | 2.5059 mL | 6.2647 mL | |
| 40 mM | 0.1879 mL | 0.9397 mL | 1.8794 mL | 4.6985 mL | |
| 50 mM | 0.1504 mL | 0.7518 mL | 1.5035 mL | 3.7588 mL | |
| 60 mM | 0.1253 mL | 0.6265 mL | 1.2529 mL | 3.1324 mL | |
| 80 mM | 0.0940 mL | 0.4699 mL | 0.9397 mL | 2.3493 mL | |
| 100 mM | 0.0752 mL | 0.3759 mL | 0.7518 mL | 1.8794 mL |
N,N'-Dimethylhydrazine dihydrochloride Related Classifications
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