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Results for "

H5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (28) ADC Antibody (1) Antibiotic (2) Apoptosis (2) Bacterial (5) Biochemical Assay Reagents (2) c-Met/HGFR (1) CCR (1) CD28 (1) Cholinesterase (ChE) (1) Complement System (2) DNA/RNA Synthesis (1) Dopamine Receptor (6) Drug Derivative (1) Drug Intermediate (4) Endogenous Metabolite (2) Enterovirus (1) Fluorescent Dye (1) Histamine Receptor (1) HIV (1) HSP (2) HSV (1) Influenza Virus (32) MicroRNA (20) MOFs (8) Pim (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Serotonin Transporter (3) Small Interfering RNA (siRNA) (2) Sodium Channel (2) Transmembrane Glycoprotein (1) Trk Receptor (1) VISTA (2)
By Research Areas:	Cancer (29) Cardiovascular Disease (4) Infection (38) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (31)
Click Chemistry:	Azide (3)
Oligonucleotides:	miRNA mimics (5) miRNA antagomirs (5) miRNA agomirs (5) MicroRNAs (20) Aptamers (1) miRNA inhibitors (5) Human Pre-designed siRNA Sets (2) siRNAs (2)

116

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

139

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15230

Geldanamycin 35+ Cited Publications	HSP Bacterial Influenza Virus Antibiotic	Infection Inflammation/Immunology Cancer
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus *H5N1* activities.

HY-103124

DOI hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
DOI hydrochloride is a serotonin 5-HT_2A/_2C receptor agonist with K_i values of 0.7 nM, 2.4 nM and 20 nM for h5-HT_2A, h5-HT_2C and h5-HT_2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice .

HY-P9914

Eculizumab 4 Publications Verification Anti-Human C5, Humanized Antibody; H5G1.1	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-B1033

Metergoline 2 Publications Verification	5-HT Receptor Dopamine Receptor Sodium Channel	Neurological Disease
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pK_is of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively. Metergoline is a high-affinity ligand for the h5-HT₇ receptor, with a K_i of 16 nM. Metergoline is also a reversible neural Na ⁺ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation .

HY-P99750

Navivumab CT-P23	Influenza Virus	Infection
Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of influenza A virus. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A .

HY-P990297

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[5].

HY-103149

SB-216641A SB-216641 hydrochloride	5-HT Receptor	Neurological Disease
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT_1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT_1B receptors over h5-HT_1D receptors. SB-216641A inhibits the function of SKF-99101H .

HY-147276

Izuforant JW1601	Histamine Receptor	Inflammation/Immunology
Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC₅₀ of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC₅₀ of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies .

HY-101094

Ocaperidone 1 Publications Verification R79598	5-HT Receptor Dopamine Receptor	Neurological Disease
Ocaperidone is an effective antipsychotic agent, acting as a potent *5-HT₂* and dopamine D₂ antagonist, and a *5-HT_1A* agonist, with K_is of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT₂, a₁-adrenergic receptor, dopamine D₂, histamine H₁ and a₂-adrenergic receptor, respectively, and a pEC₅₀ and pK_i of 7.60 and 8.08 for h5-HT_1A.

HY-13200

BRL-15572 dihydrochloride	5-HT Receptor	Neurological Disease
BRL-15572 dihydrochloride is a selective antagonist of *h5-HT1D, displays high affinity for h5-HT1D* receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses .

HY-121392

GR 125743	5-HT Receptor	Cardiovascular Disease Neurological Disease
GR 125743 is a selective *5-HT_1B/1D* receptor antagonist, with pK_is of 8.85 and 8.31 for wild-type h5-HT_1B and wild-type h5-HT_1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases .

HY-100769

Hypidone hydrochloride 2 Publications Verification YL0919	5-HT Receptor	Neurological Disease
Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT_1A receptor agonist (K_i=0.19 nM). Hypidone hydrochloride inhibits the uptake of [ ³H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC₅₀s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder .

HY-P5657

Maximin H5	Bacterial	Infection
Maximin H5 is an antimicrobial peptide derived from toad Bombina maxima .

HY-22055B

AN-12-H5 intermediate-1 (2S,4S)-1-tert-butyl 2-methyl-4-hydroxypiperidine-1,2-dicarboxylate	Drug Intermediate	Infection
AN-12-H5 intermediate-1 ((2S,4S)-1-tert-butyl 2-methyl-4-hydroxypiperidine-1,2-dicarboxylate) is an intermediate of the viral inhibitor AN-12-H5 (HY-120900) and can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-150731

Pim-1 kinase inhibitor 3	Pim	Cancer
Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC₅₀ of 35.13 nM .

HY-130178

CL-385319	Endogenous Metabolite	Infection
CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .

HY-14782

Adoprazine SLV313	5-HT Receptor Dopamine Receptor	Neurological Disease
Adoprazine (SLV313) is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine (SLV313) is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics .

HY-P5677

Bombinin H5	Bacterial	Infection
Bombinin H5 is an antimicrobial peptide derived from the skin of moth Bombina variegata .

HY-R03072A

mmu-miR-3473h-5p agomir	MicroRNA	Cancer
mmu-miR-3473h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-3473h-5p agomir mmu-miR-3473h-5p agomir

HY-101698

Alniditan Alnitidan	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) is a potent *5-HT_1B* and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for *h5-HT_1B* and h5-HT_1D receptors in HEK293 cells, respectively. Alniditan has migraine-preventive effects .

HY-139162

BGN3	Biochemical Assay Reagents	Others
BGN3 is a good substrate for the SNAP-tag ^? and H ⁵ enzymes. The activities of SNAP-tag ^? and H ⁵ enzymes on BGN3 are reasonable (IC₅₀= 15.6 and 23.5 μM, respectively) . BGN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P991447

Anti-VSIR/VISTA Antibody (SG7)	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting *VISTA/B7-H5*. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-131069A

MBX2329	Influenza Virus	Infection
MBX2329, a potent influenza virus inhibitor, specifically inhibits hemagglutinin (HA)-mediated viral entry with HIV/HA(H5) displaying IC₉₀ of 8.6 μM. MBX2329 inhibits a wide spectrum of influenza A viruses, which includes the 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, and oseltamivir-resistant A/H1N1 strains .

HY-15401

WAY 163909	5-HT Receptor	Neurological Disease Metabolic Disease
WAY 163909 is an orally active, blood-brain barrier permeable *5-HT2C* receptor-selective agonist. WAY 163909 exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

HY-120900

AN-12-H5	Enterovirus	Infection Inflammation/Immunology
AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71) .

HY-101698B

Alniditan dihydrochloride Alnitidan dihydrochloride	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) dihydrochloride is a potent *5-HT_1B* and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for *h5-HT_1B* and h5-HT_1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects .

HY-175657

5-HT2A receptor agonist-12	5-HT Receptor	Neurological Disease
5-HT2A receptor agonist-12 (compound 161-2) is a potent *5-HT2A* agonist with an EC₅₀ value of <100 nM for h5-HT2A .

HY-139163

BGSN3	Biochemical Assay Reagents	Others
BGSN3 is a good substrate for the SNAP-tag ^? and H ⁵ enzymes. The activities of SNAP-tag ^? and H ⁵ enzymes on BGSN3 are reasonable (IC₅₀=17.8 and 10 μM, respectively) . BGSN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W047496

AN-12-H5 intermediate-2	Drug Intermediate	Infection
AN-12-H5 intermediate-2 is an intermediate of the viral inhibitor AN-12-H5 (HY-120900) and can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-W451820

AN-12-H5 intermediate-3	Drug Intermediate	Infection
AN-12-H5 intermediate-3 is an intermediate of the viral inhibitor AN-12-H5 (HY-120900) and can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-169446

ALEPH hydrochloride	5-HT Receptor	Neurological Disease
ALEPH (hydrochloride) is the *h5-HT_2A* and *h5-HT_2B* partial agonist with the EC₅₀ values of 10.3 nM and 19.2 nM, respectively. ALEPH (hydrochloride) causes head twitch response in mice (ED₅₀: 0.80 mg/kg) .

HY-13200B

BRL-15572	5-HT Receptor	Neurological Disease
BRL-15572 is a selective antagonist of *h5-HT1D, displays high affinity for h5-HT1D* receptors. BRL-15572 could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses .

HY-13200A

BRL-15572 hydrochloride	5-HT Receptor	Neurological Disease
BRL-15572 hydrochloride is a selective antagonist of *h5-HT1D, displays high affinity for h5-HT1D* receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-P99886

Pexelizumab H5G1. 1-SC	Complement System Apoptosis	Cardiovascular Disease Neurological Disease
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .

HY-176721

5-HT2A receptor agonist-10	5-HT Receptor	Neurological Disease
5-HT2A receptor agonist-10 (Compound (R)-I-121.HCl) is a 5-HT2A receptor agonist, with an IC₅₀ of 2192.39 nM for h5-HT2A and h5-HT1A, respectively. 5-HT2A receptor agonist-10 can be used for the research of psychosis, mental illnesses and CNS disorders .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting *VISTA/B7-H5*. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

HY-121778

Melitracen Melitracene; N 7001; Trausabun	5-HT Receptor	Neurological Disease
Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits ³H-5-HT and ¹⁴H-5-HT with IC₅₀s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety .

HY-146306

Neuraminidase-IN-9	Influenza Virus	Infection
Neuraminidase-IN-9 (Compound 6l) is a potent influenza neuraminidase inhibitor with IC₅₀ values of 0.12, 0.049 and 0.16 µM against *H5N1, H5N2* and *H5N6*, respectively .

HY-175191

5-HT2A agonist 4	5-HT Receptor	Neurological Disease
5-HT2A agonist 4 (Compound 70) is a *5-HT2A* agonist with an EC₅₀ of 0.30  nM for h5-HT2A. 5-HT2A agonist 4 can be used for depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain research .

HY-175192

5-HT2A agonist 5	5-HT Receptor	Neurological Disease
5-HT2A agonist 5 (Compound 88) is a *5-HT2A* agonist with an EC₅₀ of 0.01  nM for h5-HT2A. 5-HT2A agonist 5 can be used for depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain research .

HY-D0287

Solvent red 52 Fluorescent red H5B	Fluorescent Dye
Solvent red 52 is a red dye. Its series of products, such as Solvent orange 60 (HY-D1177), has been used in dyeing applications of plastic materials.

HY-14782A

Adoprazine hydrochloride SLV313 hydrochloride	5-HT Receptor Dopamine Receptor
Adoprazine (SLV313) hydrochloride is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine hydrochloride is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics .

HY-174898

5-HT2C agonist-9	5-HT Receptor	Neurological Disease
5-HT2C agonist-9 (Compound 33) is a *5-HT2C* agonist with an EC₅₀ of 1.4 nM for *h5-HT2C*. 5-HT2C agonist-9 can be used in the research of diseases such as depression, drug addiction, alcoholism, PTSD and neuropathic pain .

HY-124305

ML395	Endogenous Metabolite	Infection
ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7) .

HY-15401A

WAY 163909 (hydrochloride)	5-HT Receptor	Neurological Disease Metabolic Disease
WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable *5-HT2C* receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

HY-B1033R

Metergoline (Standard)	5-HT Receptor Dopamine Receptor Sodium Channel Reference Standards	Neurological Disease
Metergoline (Standard) is the analytical standard of Metergoline. This product is intended for research and analytical applications. Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation .

HY-177637

H5N1 aptamer sodium	Influenza Virus	Infection
H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.

HY-R01686

hsa-miR-548h-5p mimic	MicroRNA	Cancer
hsa-miR-548h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-548h-5p mimic hsa-miR-548h-5p mimic

HY-R00189

hsa-miR-1273h-5p mimic	MicroRNA	Cancer
hsa-miR-1273h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-1273h-5p mimic hsa-miR-1273h-5p mimic

Cat. No.	Product Name	Type

HY-50097

3-Bromo-2-methylaniline

Biochemical Assay Reagents

3-Bromo-2-methylaniline is an aromatic amine compound and aniline derivative that serves as a starting material and synthetic precursor. 3-Bromo-2-methylaniline acts as a starting material for the synthesis of 4-bromo-1H-indazole and racemic 3,9-dibromo-4,10-dimethyl-6H,12H-5,11-methanodibenzodiazocine. It also serves as a precursor for the regioselective bromination and subsequent deamination to synthesize 1,2-dibromo-3-methylbenzene .

HY-15401A

WAY 163909 (hydrochloride)

Biochemical Assay Reagents

WAY 163909 hydrochloride is an orally active, blood-brain barrier permeable 5-HT2C receptor-selective agonist. WAY 163909 hydrochloride exhibits an EC₅₀ of 8 nM and a K_i of 10.5 nM for h5-HT2C. Instead of triggering apoptosis, WAY 163909 hydrochloride induces anorectic, antipsychotic-like, antidepressant-like, anti-aggressive and anti-compulsive effects. WAY 163909 hydrochloride alleviates ketamine-induced hypothermia, but impairs sexual function at high doses. With rapid antidepressant-like properties, WAY 163909 hydrochloride can be used in research related to obesity, schizophrenia, depression, obsessive-compulsive disorder, and anesthesia-induced hypothermia .

Cat. No.	Product Name	Target	Research Area

HY-P5657

Maximin H5	Bacterial	Infection
Maximin H5 is an antimicrobial peptide derived from toad Bombina maxima .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various *H5N1, some H9N2, and H1N1* strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), influenza virus, and *H5N1* influenza .

HY-P5677

Bombinin H5	Bacterial	Infection
Bombinin H5 is an antimicrobial peptide derived from the skin of moth Bombina variegata .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9914

Eculizumab 4 Publications Verification Anti-Human C5, Humanized Antibody; H5G1.1	Complement System	Cardiovascular Disease Neurological Disease
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice. Eculizumab can be used in hemolysis studies .

HY-P99750

Navivumab CT-P23	Influenza Virus	Infection
Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of influenza A virus. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A .

HY-P990297

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[5].

HY-P991059

VIS-410	Influenza Virus	Infection
VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits influenza virus replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as H1N1, H3N2, *H5N1, and H7N9* (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .

HY-P99620

Firivumab CT-P22; CT120	Influenza Virus	Infection
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .

HY-P991447

Anti-VSIR/VISTA Antibody (SG7)	VISTA	Cancer
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting *VISTA/B7-H5*. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99886

Pexelizumab H5G1. 1-SC	Complement System Apoptosis	Cardiovascular Disease Neurological Disease
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .

HY-P991421

W0180	VISTA	Cancer
W0180 is a human IgG1 monoclonal antibody (mAb) targeting *VISTA/B7-H5*. W0180 has the potential to activate T cells. W0180 can be used in solid tumors research .

HY-P990472

Anti-MSPR/RON/CD136 Antibody (H5B14) H5B14	c-Met/HGFR	Inflammation/Immunology
Anti-MSPR/RON/CD136 Antibody (H5B14) is a humanized antibody expressed in CHO cells, targeting MSPR/RON/CD136. Anti-MSPR/RON/CD136 Antibody (H5B14) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 156.7 kDa. The isotype control for Anti-MSPR/RON/CD136 Antibody (H5B14) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990128

Anti-Rat CD80/B7-1 Antibody (3H5)	CD28	Inflammation/Immunology Cancer
Anti-Rat CD80/B7-1 Antibody (3H5) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat CD80/B7-1. Anti-Rat CD80/B7-1 Antibody (3H5) blocks a costimulatory signals for T-cell activation. Anti-Rat CD80/B7-1 Antibody (3H5) can be used for the researches of cancer and immunology .

HY-P990589

GBR-900 BXL-1H5	Trk Receptor	Inflammation/Immunology
GBR-900 is a humanized antibody expressed in CHO that targets TrkA/NTRK1. GBR-900 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for GBR-900 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992083

Anti-Influenza HA Antibody (CR9114)	Influenza Virus	Infection
Anti-Influenza HA Antibody (CR9114) is an antibody against influenza virus hemagglutinin. Anti-Influenza HA Antibody (CR9114) binds to the conserved hemagglutinin (HA) stalk region of influenza A and B viruses, and mediates cross-subtype neutralization. Anti-Influenza HA Antibody (CR9114) is applicable for influenza-related research .

HY-P992488

ZV05 ZV0501 Antibody	Transmembrane Glycoprotein ADC Antibody	Cancer
ZV05 (ZV0501 Antibody) is an anti-5T4 monoclonal antibody with an EC₅₀ of 4.3 ng/mL against h5T4. ZV05 does not induce apoptosis or interfere with cell cycle progression. ZV05 accumulates specifically in *5T4*-positive tumor xenografts. ZV05 can serve as the antibody component of antibody-active molecule conjugates (ADCs) to bind the 5T4 glycoprotein, thereby enabling targeted delivery of toxins. ZV05 is used in studies of *5T4*-positive cancers, including triple-negative breast cancer .

Host:	Mouse (1) Rabbit (5)
Reactivity:	Human (6) Rat (1) Mouse (1)
Application:	IHC-P (4) ICC/IF (4) IHC-F (1) WB (4)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (6) Biotin (8)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83276

	ALAS1 Antibody (YA3021) ALAS1; ALAS-H; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; ALAS3; ALASH	WB, ICC/IF	Human
	ALAS1 Antibody (YA3021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ALAS1.

HY-P81427

	B7H4 Antibody (YA1172) B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291	IHC-P	Human
	B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.

HY-P81427A

	B7H4 Antibody (YA1172)(PBS only) B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291	IHC-P	Human
	B7H4 Antibody (YA1172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to B7H4.

HY-P85541

	CHRDL1 Antibody (YA5233) CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.	WB, IHC-P, ICC/IF	Human
	CHRDL1 Antibody (YA5233) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CHRDL1.

HY-P810369

	B7H4 Antibody (YA9689) B7 family member, H4, B7 H4, B7 homolog 4, B7 superfamily member 1, B7 superfamily, member 1, B7-H4, B7h.5, B7h4, B7S1, B7x	WB, ICC/IF	Human, Mouse, Rat
	B7H4 Antibody (YA9689) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to B7H4.

HY-P810493

	B7H4 Antibody (YA9786) B7H4, UNQ659/PRO1291, VTCN1, V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7-H4	WB, IHC-F, IHC-P, ICC/IF	Human
	B7H4 Antibody (YA9786) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to B7H4.

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Cat. No.	Product Name		Classification

HY-139162

BGN3		Azide
BGN3 is a good substrate for the SNAP-tag ^? and H ⁵ enzymes. The activities of SNAP-tag ^? and H ⁵ enzymes on BGN3 are reasonable (IC₅₀= 15.6 and 23.5 μM, respectively) . BGN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139163

BGSN3		Azide
BGSN3 is a good substrate for the SNAP-tag ^? and H ⁵ enzymes. The activities of SNAP-tag ^? and H ⁵ enzymes on BGSN3 are reasonable (IC₅₀=17.8 and 10 μM, respectively) . BGSN3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-123199

Serotonin azidobenzamidine SABA		Azide
Serotonin azidobenzamidine is an arylazido derivative of 5-hydroxytryptamine (HY-B1473A). Serotonin azidobenzamide competitively inhibits [3H]5-hydroxytryptamine uptake by rat cortical synaptosomes in the dark with a K_i of 130 nM .

Cat. No.	Product Name		Classification

HY-R03072A

mmu-miR-3473h-5p agomir		MicroRNAs miRNA agomirs
mmu-miR-3473h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-177637

H5N1 aptamer sodium		Aptamers
H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.

HY-R01686

hsa-miR-548h-5p mimic		MicroRNAs miRNA mimics
hsa-miR-548h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R00189

hsa-miR-1273h-5p mimic		MicroRNAs miRNA mimics
hsa-miR-1273h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03471

mmu-miR-669h-5p mimic		MicroRNAs miRNA mimics
mmu-miR-669h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03072

mmu-miR-3473h-5p mimic		MicroRNAs miRNA mimics
mmu-miR-3473h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RS05902

GTF2H5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GTF2H5 Human Pre-designed siRNA Set A contains three designed siRNAs for GTF2H5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-R03471A

mmu-miR-669h-5p agomir		MicroRNAs miRNA agomirs
mmu-miR-669h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00189A

hsa-miR-1273h-5p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-1273h-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03180

mmu-miR-466h-5p mimic		MicroRNAs miRNA mimics
mmu-miR-466h-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01686

hsa-miR-548h-5p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548h-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI00189

hsa-miR-1273h-5p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-1273h-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03072

mmu-miR-3473h-5p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-3473h-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03471

mmu-miR-669h-5p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-669h-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03180

mmu-miR-466h-5p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-466h-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R00189A

hsa-miR-1273h-5p agomir		MicroRNAs miRNA agomirs
hsa-miR-1273h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03180A

mmu-miR-466h-5p agomir		MicroRNAs miRNA agomirs
mmu-miR-466h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01686A

hsa-miR-548h-5p agomir		MicroRNAs miRNA agomirs
hsa-miR-548h-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03180A

mmu-miR-466h-5p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-466h-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03072A

mmu-miR-3473h-5p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-3473h-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01686A

hsa-miR-548h-5p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548h-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03471A

mmu-miR-669h-5p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-669h-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RS12683

SEPTIN4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SEPTIN4 Human Pre-designed siRNA Set A contains three designed siRNAs for SEPTIN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Species:	Virus (115) Human (13) Rhesus Macaque (4) Rat (1) Mouse (4) Cynomolgus (2)
Tag:	His (126) Tag Free (2) Avi (4) Fc (15)
Source:	HEK293 (108) Sf9 insect cells (29) E. coli (2)

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