Neuraminidase-IN-16
Neuraminidase-IN-16 (Compound 43b) is a potent neuraminidase inhibitor with IC50s of 0.031, 0.15, 0.25, 0.60, 0.63 and 10.08 μM against neuraminidase of H5N1, H5N8, H1N1, H3N2, H5N1-H274Y and H1N1-H274Y, respectively.
For research use only. We do not sell to patients.
- CAS No.: 3049424-11-2
- Formula: C26H35FN2O4
- Molecular Weight:458.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | CC50 |
>200 μM
Compound: 43b
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Cytotoxicity against chicken embryo fibroblast cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against chicken embryo fibroblast cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 36931117] |
| Fibroblast | EC50 |
2.1 μM
Compound: 43b
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Anti-influenza virus activity against Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
Anti-influenza virus activity against Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
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[PMID: 36931117] |
| Fibroblast | EC50 |
2.28 μM
Compound: 43b
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Anti-influenza virus activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
Anti-influenza virus activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
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[PMID: 36931117] |
| MDCK | CC50 |
>250 μM
Compound: 43b
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Cytotoxicity against dog MDCK cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 36931117] |
Neuraminidase-IN-16 (Compound 43b; 48 h) shows anti-influenza virus activity with EC50s of 2.10±0.44 μM and 2.28±0.67 μM for H5N1 and H5N8, respectively in Chicken Embryo Fibroblast cells (CEFs)[1].
Neuraminidase-IN-16 (48 h) shows anti-influenza virus activity with EC50s of 0.20±0.01 μM and 11.3±2.5 μM for H1N1 and H3N2, respectively in MDCK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Neuraminidase-IN-16 has no ability to pass through the blood-brain barrier[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SPF chicken embryonated egg infected with H5N1 and H5N8 virus strains[1]
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Dosage:0.039, 0.156, 0.625, 2.5 and 10 mM; 100 uL
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Administration:A 1 mm diameter hole was drilled into the egg shell on the side where the embryo was located, the mixture was injected into the egg, and the holes were sealed by wax.
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Result:Showed 100% protective effect at the highest tested concentration (10 mM).
Chemical Information
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CAS No. 3049424-11-2
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Molecular Weight 458.57
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Formula C26H35FN2O4
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SMILES
CCC(O[C@@H]1C=C(C[C@@H]([C@H]1NC(C)=O)NCC2=CC=C(C(F)=C2)C3=CCCC3)C(O)=O)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuraminidase-IN-16 Related Classifications
HY-149088 Related Classifications
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