1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. BRL-15572 dihydrochloride

BRL-15572 dihydrochloride 

Cat. No.: HY-13200 Purity: 99.78%
Handling Instructions

BRL-15572 dihydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.

For research use only. We do not sell to patients.

BRL-15572 dihydrochloride Chemical Structure

BRL-15572 dihydrochloride Chemical Structure

CAS No. : 193611-72-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 74 In-stock
Estimated Time of Arrival: December 31
5 mg USD 67 In-stock
Estimated Time of Arrival: December 31
10 mg USD 106 In-stock
Estimated Time of Arrival: December 31
50 mg USD 370 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

BRL-15572 dihydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].

IC50 & Target[1]

5-HT1D Receptor

 

In Vitro

BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1].
BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

479.87

Formula

C₂₅H₂₉Cl₃N₂O

CAS No.

193611-72-2

SMILES

OC(CN1CCN(C2=CC(Cl)=CC=C2)CC1)C(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (520.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0839 mL 10.4195 mL 20.8390 mL
5 mM 0.4168 mL 2.0839 mL 4.1678 mL
10 mM 0.2084 mL 1.0419 mL 2.0839 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BRL-15572BRL15572BRL 155725-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorh5-HT1DInhibitorinhibitorinhibit

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Product Name:
BRL-15572 dihydrochloride
Cat. No.:
HY-13200
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