BRL-15572 hydrochloride

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BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.

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BRL-15572 hydrochloride Chemical Structure

CAS No. : 1173022-77-9

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Other In-stock Forms of BRL-15572 hydrochloride:

Other Forms of BRL-15572 hydrochloride:

BRL-15572 dihydrochloride In-stock

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_1D Receptor

In Vitro

BRL-15572 has 60-fold higher affinity for h5-HT1D (pK_i=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells^[1].
BRL-15572 (0.1 nM-10 μM) stimulates [³⁵S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test^[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

443.41

Formula

C₂₅H₂₈Cl₂N₂O

CAS No.

1173022-77-9

SMILES

OC(C(C1=CC=CC=C1)C2=CC=CC=C2)CN3CCN(C4=CC=CC(Cl)=C4)CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20. [Content Brief]

[2]. Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279. [Content Brief]

[3]. Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74. [Content Brief]