1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. BRL-15572 hydrochloride

BRL-15572 hydrochloride 

Cat. No.: HY-13200A
Handling Instructions

BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.

For research use only. We do not sell to patients.

BRL-15572 hydrochloride Chemical Structure

BRL-15572 hydrochloride Chemical Structure

CAS No. : 1173022-77-9

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Description

BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].

IC50 & Target[1]

5-HT1D Receptor

 

In Vitro

BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1].
BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1].

In Vivo

BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].

Molecular Weight

443.41

Formula

C₂₅H₂₈Cl₂N₂O

CAS No.

1173022-77-9

SMILES

OC(C(C1=CC=CC=C1)C2=CC=CC=C2)CN3CCN(C4=CC=CC(Cl)=C4)CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BRL-15572BRL15572BRL 155725-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorh5-HT1DInhibitorinhibitorinhibit

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Product Name:
BRL-15572 hydrochloride
Cat. No.:
HY-13200A
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